I reviewed 100+ conference abstracts over the weekend. A 🧵 with some of my takeaways on how to craft an excellent abstract: 1/12

Our recent Swanton Lab work on the genomic evolution of lung cancer patient-derived xenograft (PDX) models in TRACERx is now bioRxiv 🐁 biorxiv.org/content/10.110… #PDXmodels #cancerresearch #lungcancer #NSCLC A short thread (1/6) 🧵👇

'Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers' nature.com/articles/s4301…

Opening patient evening UCL Cancer Institute, supported by CRUKCOLcentre. Loads of enthusiastic volunteers from @Marcrmansour, Chris Tape @Parrinello_Lab, Quezada Lab, Sibylle Mittnacht and more labs made it possible, may this be the beginning of a new PPIE movement UCL Cancer Institute?

Today, @nature and natureMedicine are proud to publish amazing new insights into lung cancer evolution from the #TRACERx consortium. Updated collection: nature.com/collections/ha… Great author threads👇

Can ctDNA can be harnessed to identify ongoing karyotype evolution and heterogeneity in pancreatic cancer? Great work from James Black Ariana Huebner …thread👇

Happy to share our work looking at induction failure in childhood and young adult T-ALL. A short thread on the main findings…. ascopubs.org/doi/10.1200/JC…

June really appears to be my lucky month - our new preprint is out on Research Square! 😍 Together with Mike Spencer Chapman, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system researchsquare.com/article/rs-308…. [1/x]

Excited to announce our new method HATCHet2 for inferring haplotype- and clone-specific copy number from bulk samples! HATCHet2 extends HATCHet to infer mirrored-subclonal CNAs, and introduces new binning and clustering approaches. biorxiv.org/content/10.110…

Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in Nature Cancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy. Broad Institute Wellcome Sanger Institute Gad Getz Laboratory Thread below 🧵 nature.com/articles/s4301…

Officially became DDrr in this seminar room earlier today 🤓🧐🥳. Thanks to everyone who have made this journey so special :-)

Johns Hopkins is offering FREE research courses online. Here are 10 courses you can audit to elevate your skills (links below):

Can everyone please congratulate Dr Chuling Ding on being awarded her #PhD in Cancer Genomics? Inquisitive, systematic and driven, this PhD is so well deserved. Congrats Chuling! UCL Cancer Institute UCL Faculty of Medical Sciences

Our latest paper: measurement of cancer evolutionary dynamics at massive scale, using just a methylation array on bulk DNA. Find evolutionary dynamics strongly determine clinical outcomes in lymphoid cancers. Fab collab with Inaki Martin & Martí Duran-Ferrer, & led by Calum Gabbutt. A🧵⬇️

Excited to share the first preprint of my PhD Wellcome Sanger Institute looking into the prevalence and genetic mechanisms of gene misexpression in 4,568 whole blood RNA-seq samples from the INTERVAL cohort. biorxiv.org/cgi/content/sh…

Spatial host–microbiome sequencing reveals niches in the mouse gut go.nature.com/3sGmJbU

CONIPHER, our method for automated reconstruction of tumour subclonal structure and phylogeny that we used in our recently published TRACERx studies, is now out in Nature Protocols! (nature.com/articles/s4159…). Welcome to the CONIPHER TREEtorial, just in time for Christmas! 🌲 1/n

From nature - Why we need an academic career path that combines science and art: nature.com/articles/d4158… A thought provoking discussion on the relationship between science and art. The science-art dichotomy has always seemed arbitrary to me

Thrilled to welcome Javier Herrero 🇪🇺 as the Project Director of Bioinformatics at Asgard Therapeutics. With 25 years of expertise, Javier will play a key role in identifying genetic and epigenetic factors for reprogramming and treatment efficacy.🌟 Welcome to the team, Javier!

Very excited to release Sequoia, our pipeline for phylogenetic tree reconstruction from mutations in normal cells. A detailed description is now published in Nature Protocols! nature.com/articles/s4159…