Wow! 👏🏿👏🏿👏🏿 to @sheffieldsu on an incredible SEVEN year streak for Best Students’ Union award at @WhatUni tonight! Congratulations to all the students, staff and all in the @SheffieldUni community. You’re literally the best. #WUSCA

🚨Transcription and Chromatin UK is back for 2024🚨
We will be in Newcastle from 25th to 27 Sept. Register your interest so you're the first to know when registration opens 🧬
biochemistry.org/events-and-tra…

A new targeted treatment which could transform the lives of children diagnosed with glioma has been approved for use on the NHS

Read about this treatment ➡️ bit.ly/3w7bz1C

#Research #BrainTumourResearch #RaisingAwareness

WHAT % OF YOUR TARGET BIOMOLECULES ARE YOU REALLY IMAGING?

The *labeling efficiency* of your experiment is extremely important for image quality and quantitative results in super-resolution!

Super excited about our new article in Nature Methods! 🤩

nature.com/articles/s4159…

Excited to share our new paper in Cell on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/

New - electrochemical control of blinking duty cycle for Alexa 647 in a standard STORM buffer ⚡🥃🔬

The authors demonstrate greatly reducing random blinking and photobleaching, allowing for accurate molecular counting: go.nature.com/3UwT3sY

#SuperResolution #Microscopy #SMLM

Now Online The senescence-associated secretory phenotype and its physiological and pathological implications dlvr.it/T5vgzn

Thank you to Paul Blomfield MP, Steve Brine MP, Steve Tuckwell MP, Sarah Owen MP, Nickie Aiken MP for Cities of London & Westminster, Daisy Cooper MP 🔶, Flick Drummond MP, George Freeman MP FRSA, Diana Johnson DBE MP 🇬🇧🇺🇦🌈, Wera Hobhouse MP 🔶 🇺🇦, lan Byrne MP for supporting our calls for a National Brain Tumour Strategy today #ItsANoBrainer

Regulation of Chromatin Modifications through Coordination of Nucleus Size and Epithelial Cell Morphology Heterogeneity biorxiv.org/cgi/content/sh… #biorxiv_biophys

beautiful work revealing actin bundles in the Plasmodium nucleus

Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum biorxiv.org/content/10.110…

Another cool review out! Mathilde Mathieu Aleksi Isomursu and Johanna Ivaska take a deep dive into positive and negative durotaxis in cell migration :-

Positive and negative durotaxis – mechanisms and emerging concepts : journals.biologists.com/jcs/article/13…

Come join us in Oxford as an Associate Professor in Molecular and Cellular Biochemistry.
We are considering a wide range of research areas, but I would note that we have a vibrant chromatin and gene regulation community.
Happy to answer questions if you are interested.
Please RT!

📢 Pioneer and repressing transcription factors regulate nucleus-wide chromatin motions and architecture - check out our work led by Haitham Shaban pnas.org/doi/epdf/10.10… - more details 👇

High Expectation on #Tim3 for #DIPG a great summary of the new progress and ideas from #AACR2024

American Association for Cancer Research Annual Meeting

linkedin.com/pulse/continui…

Detecting directed motion and confinement in single-particle trajectories using hidden variables biorxiv.org/cgi/content/sh… #biorxiv_biophys

Do you use tagged lamins? In work done by amazing but twitterless Jacob Odell, we found that despite (mostly) normal localization, even small N-terminal tags such as FLAG-tags can impair specific functions of lamin A while not affecting other functions.
biorxiv.org/content/10.110…

A great symposium on Nuclear Mechano-Genomics. Nice to hear most recent work a this frontier. meetings.embo.org/event/24-mecha…

The crisis in the UK University sector that nobody seems to be talking about.

newstatesman.com/comment/2024/0…

In @elife: Mitosis sets nuclear homeostasis of cancer cells under confinement. The nuclear membrane tension-sensing mechanism engaging cPLA2 is at play:
doi.org/10.7554/eLife.…

Happy and excited to share our new bioRxiv on long-term single-molecule imaging!! 🔬💥 #Breakthrough , #ProudPI
biorxiv.org/content/10.110…
ZMBP SFB1101 Universität Tübingen #TRR356
Nano-🧵👇