Such an honor to be part of the YPO Longevity Summit with such incredible speakers!

Impact of #fasting & #ketogenic interventions on the NLRP3 inflammasome: A narrative review
sciencedirect.com/science/articl…

Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors

Mental and metabolic health are inseparable.

#BrainEnergy

pnas.org/doi/10.1073/pn…

this is for christine…we talked about mental health today…i did this- #deconstructingstigma with McLean Hospital-spoke about depression…you’re not alone…i love you.

Brain energy metabolism plays a key role in both neurodevelopment and neurodegeneration.

The science is complex, but it is clear, unequivocal, and understandable.

cell.com/immunity/fullt…

Perhaps it's time to begin using a transdiagnostic model of neuropsychiatric disorders.

There is a lot of overlap in symptoms among disorders.

The much bigger problem is co-morbidity.

If you are being treated for one mental disorder, you likely have more than one.

There are many possible strategies to improve mitochondrial function.

This research explores the possibility of engineering exosomes to specifically target mitochondria in brain cells.

In the meantime, we can use lifestyle medicine.

pubs.acs.org/doi/10.1021/ac…

Neurotransmitters, trauma, loneliness, hormones, genetics, substance abuse, neuroinflammation…

Can’t see the forest for the trees?

Metabolism
#BrainEnergy

since it’s pretty clear that mild depression is over-treated and severe mental illness under treated I don’t see how this could help much and could cause harm with side effects. Severe mental illness needs more than just a pill for support as well.

Limited access to antidepressant prescriptions is NOT the cause of our depression epidemic.

Failure to address the root causes of depression is the problem.

Let's address the real issues.

Brain Energy by Chris Palmer, MD has totally changed how I see the world

If you know anyone suffering from bipolar, anxiety, depression or other mental health issues

Please give it a read & see what you think

If you want, I will gift you a copy

Possibly even more controversially, similar could be said of #autism :

Autism is a syndrome—a constellation of signs/symptoms with unknown cause.

The time has come to begin looking for the myriad possible causes and treating them.

It is complex.

Nonetheless, it's possible.

'It is hard to imagine the anguish experienced by the parents, relatives, and friends of a child who has taken his or her own life. That such an event could be precipitated by a supposedly beneficial drug is a catastrophe. The idea of that drug's use being based on the selective…

The existence, survival, and adaptability of living organisms centers on metabolism.

Medical conditions can cause “depression.” Health care providers need to assess for them.

Sylvia Fogel MD Agree. It assumes depression is a simple condition and simple to treat. It’s actually a complex condition that could signify a wide range of serious medical conditions, including cancer, hormone imbalance, autoimmune disorder, early signs of a neurodegenerative disorder, etc.…

Should SSRIs be available over the counter?

Having seen many patients become manic on them, or develop side effects, or have great difficulty discontinuing them, it seems dangerous to me.

What do you think?

statnews.com/2024/04/08/tim…

Treatments for mental health conditions can sometimes be the polar opposite.

For example, if you have anxiety and fear, you may want to:

1. Take deep breaths and think about something else.

OR

2. Purposely expose yourself to your anxiety and fears.

Both *can* work.