Join the innovative Translational Sciences group at #Biogen and be at the forefront of drug discovery. Leverage cutting-edge human genetics insights and collaborate with top-notch scientists to drive drug pipeline forward. Apply now! smrtr.io/kr3gC

Very excited that the latest from the PGC Consortium PTSD group is now out in Nature Genetics!

Headline: 95 loci implicated with PTSD, now in the rapid-discovery phase of psychiatric GWAS.

nature.com/articles/s4158…

Thread and ReadCube link to follow

Dr. Joshua Gordon to Step Down as Director of the National Institute of Mental Health - National Institute of Mental Health (NIMH) nimh.nih.gov/news/science-n…

Exciting news! Our latest study has been published in Nature Communications: nature.com/articles/s4146…

Congrats and huge thanks to Chia-Yen Chen, Heiko Runz, and all our other co-authors, Tian Ge, Todd Lencz, Max Lam, Jimmy Liu, Ellen Tsai for their exceptional contributions!

PREPRINT ALERT! We performed large-scale Mendelian Randomization of circulating protein levels on schizophrenia, bipolar, MDD, and cognition, revealing 109 causal associations (44 novel) involving 88 proteins across the four phenotypes. Tweetorial Monday.

medrxiv.org/content/10.110…

🧬 Join Biogen's Discovery Genetics Co-op this summer! Dive into large-scale genomic data and contribute to drug dev programs for psychiatric and neurodegenerative disorders. Gain hands-on experience and guidance from experts in human genetics. Apply here: smrtr.io/hRqdb

Thrilled to announce our latest study published in Cell Genomics !
cell.com/cell-genomics/…
Big shoutout to our amazing collaborators Chia-Yen Chen Tian Ge Hailiang Huang Anne Feng and many others!

#GWAS #TaiwanBiobank 🧬

The #gnomAD team is proud to announce the release of gnomAD v4! The v4 dataset includes 730,947 exomes & 76,215 genomes, which is ~5x larger than the v2 & v3 releases combined, & includes nearly 120K indivs of non-European genetic ancestry broad.io/gnomad_v4 #ASHG23 (1/11)

On the problem of inflation in TWAS

Does TWAS yield inflated p-values?

I'm delighted to release the first half of my new open-access online textbook in human population genetics:
web.stanford.edu/group/pritchar…

If you are going to read a half of a brilliant primer on population genetics, that is as entertaining as it is informative, make it the first half of this; I learnt a lot from it
⁦Jonathan Pritchard⁩ web.stanford.edu/group/pritchar…

Yes, Virginia, summary statistics from many cancer genome-wide association studies are publicly available! #sumstats #cancer #gwas docs.google.com/document/d/13j…

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in Cell today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful…

We are thrilled to announce the next exciting chapter of FinnGen! After completing the construction of the research resource of 500,000 Finns, we will now move to the phase of understanding disease mechanisms and disease progression.
finngen.fi/en/finnish-gen…

Since 2017, the FinnGen study coordinated by FIMM researchers has developed into one of the world’s leading biobank-based genomic research projects. FinnGen will now move to a new phase, searching for genetic clues to disease progression.
helsinki.fi/en/news/genes/…

[Chen et al. 2023 NG; pubmed.ncbi.nlm.nih.gov/37231097/] looked for rare coding associations with three phenotypes: Edu, Reaction Time, VNR. They found 5 associations with Edu (+3 others), demonstrating that Edu can be a reasonable and accessible proxy phenotype for rare var studies.

Are protein and RNA correlated? 12 papers and examples 👇 🧵 what do you think?

In Trends in Genetics today, Hilary Martin and I deliver a spotlight (sciencedirect.com/science/articl…) on the recent exome-wide association study of education and cognitive ability. Our concluding paragraph states:

The study by Chen et al. provides a compelling rebuke to those who have…

Alexander Strudwick Young Trends in Genetics Hilary Martin Thank you Alexander Strudwick Young and Hilary Martin for this outstanding Trends in Genetics feature of our exome study on cognitive function by @ChiaYenChen & our fabulous collaborators. Your thoughtful, balanced discussion is much appreciated. Absolutely worth a read! nature.com/articles/s4158…

Our Nature Genetics cognitive function exome study rdcu.be/dcZRe summarized GenomeWeb