Our paper is out Nature Medicine Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease rdcu.be/8eCo Data is at susztaklab.org Congrats @CX_quorly

How do the ‘inner lives’ of cells in the early mammalian embryo change over time? Read this excellent N&V by Jay Shendure and Chengxiang Qiu to find out go.nature.com/3eM8C9J

Very proud of Waddington's Waterslide, drawn by my 13 y/o daughter (for $5) as the original sketch for a Nature News & Views with Chengxiang Qiu on a terrific new paper from the Steltzer and Tanay groups at Weizmann Institute. go.nature.com/3eM8C9J

After >2000 commits, I am thrilled to announce the release of dynamo 1.0.0! In this release, we pushed the limits of our continuous vector field approaches to develop an awesome set of techniques to enable functional and predictive analyses of (time-resolved)scRNA-seq experiments

Excited to share a preprint about our project in which we aim to computationally reconstruct the cellular trajectories of mammalian embryogenesis, which started in my lab rotation at the beginning of my PhD. Many thanks to Jay Shendure and my rotation mentor Junyue !!

Our latest preprint, from the brilliant Chengxiang Qiu, systematically integrates a series of single cell RNA-seq datasets that collectively span mouse gastrulation and organogenesis (E3.5 – E13.5) (1/4)

Our latest preprint, from the ingenious @bethkarenmartin, is an optimized, streamlined version of the three-level combinatorial indexing (split/pool) protocol for single cell RNA-seq (sci-RNA-seq3), originally developed by Junyue. 1/4 arxiv.org/pdf/2110.15400…

It’s finally here! We built an artificial DNA-based recording system named DNA Ticker Tape – we can record the order of biological events in the genome, including those of the human cells! (1/12) biorxiv.org/content/10.110…

My interests in history makes me want to RECORD and WRITE cellular history too. How can we learn the past of a cell and understand why it is what it is right now? Can we record histories into genomes? Check out our latest preprint about ENGRAM biorxiv.org/content/10.110…

It is with great sadness that we share the news that Dr. Casey Brown passed away on Saturday, March 18. He was a friend, colleague, and mentor to so many in the GCB and CAMB communities, as well as the scientific community as a whole, and will be deeply missed.

Excited to share our lab's latest preprint, led by Chengxiang Qiu, @bethkarenmartin & Ian Welsh of The Jackson Laboratory. We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup. Preprint: tinyurl.com/2nhe4mm9 1/n

Fantastic work delineating how life is generated by 12 million single-cell transcriptomes in a single study (from E8 to P0)! Congratulations to my former colleagues at Jay Shendure lab, especially Chengxiang Qiu and @bethkarenmartin !

Our latest out today in nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg

Congrats,Chengxiang Qiu, @bethkarenmartin, Ian, and Jay Shendure! What a fantastic paper which would be a long-years basis for the developmental biology field. "A single-cell time-lapse of mouse prenatal development from gastrula to birth". nature.com/articles/s4158…

Incredibly proud to share that I recently joined UCSF Bioengineering & Therapeutic Sciences UC San Francisco as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳

New synthetic biology / gene regulation lab opening in Zurich! We’re studying how to control cell state transitions – for example, making diseased cells healthy or creating new cellular functions – using systematic perturbations, single-cell genomics and machine learning. 🧵1/4

New paper from my lab and Jay Shendure lab! Led by the brilliant @Zukailiu and Chengxiang Qiu. We tackle a question: How do anterior and posterior progenitor cells cooperate to self-organize into an embryonic structure (termed AP-gastruloid)? (1/n) biorxiv.org/content/10.110…