#HappeningNow BWH Neuroscience Day 2024 continues with poster presentations from across the department. 👩‍🔬 🧠

Excited to share our study investigating the genetics of combined lipid patterns led by Tom Gilliland Jacqueline Dron, PhD! ahajournals.org/doi/10.1161/CI… Circulation Research [1/8]

🚨Postdoc Opening🚨 We're seeking a skilled scientist to lead research in multiomics❗️ Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease Lab: georgakis-lab.isd-muc.de Position: findapostdoc.com/search/Job-Det… Please RT!

GWAS of 2024 AI-derived (mainly imaging) human disease endophenotypes, including genetic correlations and Mendelian randomization associations with disease endpoints🧬 Summary stats to be made available upon publication medrxiv.org/content/10.110…

Honored to have you join the faculty Priya. Great things now and ahead.

The effects of a polygenic risk score for BMI on obesity and obesity-related morbidities are offset by a healthy lifestyle 🧬🍲🏃‍♀️ 👉evidence of additive & multiplicative interaction 👉high PRS ⬆️ the effect of unhealthy lifestyle on obesity risk sciencedirect.com/science/articl…

- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit

Many thanks to study co-authors Sam Freesun Friedman, Shino Kany, Rahul Mahajan, Clay Turner, @steven_lubitz, Mahnaz Maddah and 🙏 as always for mentorship Patrick Ellinor, Chris Anderson Broad Institute Mass General Heart MassGeneral News

I extend my deepest gratitude to my co-authors @rainermpg, Saman Doroodgar Jorshery MD, MPH, Vineet Raghu, Pradeep Natarajan, Tiffany Bellomo, and Chris Anderson for their invaluable contributions, and especially to my PI Marios Georgakis for making this possible and for his immense support

Many cool findings & a great resource for future research in atherosclerosis 📊GWAS summ stats to be posted on NHGRI-EBI GWAS Catalog Phenomenal work by star Murad⭐️ Great collaboration with Chris Anderson @rainermpg Saman Doroodgar Jorshery MD, MPH Vineet Raghu Pradeep Natarajan Tiffany Bellomo

Comprehensive proteome-wide Mendelian randomization for 355 phenotypes in 3 ancestries 👉N=35,559 European, 1,871 African, 1,823 East Asian 👉SomaScan & Olink 👉extensive sensitivity analyses 📊Results browsable here: broad.io/protein_mr_atl… 📰Preprint: medrxiv.org/content/10.110…

You're never behind the genetic 8-ball. Making healthy lifestyle choices reduces your risk of age-related brain disease even if you have a genetic predilection. neurology.org/doi/10.1212/WN…. Brigham and Women's Neurology MGH Neurology CGM at MGH Broad Institute

We made a lot of effort to put all summary statistics available. There are in four different places: 1) NIAGADS: dss.niagads.org/collections/kn…, 2) GWAS catalog, GCST90317902–GCST903193033, 3) Pheweb browser ontime.wustl.edu, and 4) our website: neurogenomics.wustl.edu/open-science/r…

Another key resource for CNS genomic and drug target discovery research❗️ 👉pQTLs for 6,361 CSF proteins (SomaScan aptamers) 👉N=3,506 samples 👉3,885 associations for 1,883 proteins 📜paper: nature.com/articles/s4158… 📊summ stats: wustl.app.box.com/s/3kms8fjz228q…

Thanks Tom. You’ve done so much for the field that I appreciate this tremendously.

Spatial proteomics in human carotid atherosclerotic plaques (N=118). A great weekend read❗️ 👉subregions isolated with microdissection (lipid core, fibrous cap, tunica media) 👉mass-spec proteomics 👉proteome-defined subclusters across subregions 👉biological enrichment across

Our study in Nephrology Journal explores the interplay between #CKD and ischemic #stroke. Findings highlight the need for integrated care strategies to improve outcomes and reduce stroke risk in CKD patients. leonard yeo Lee Ying Clara Ngoh Chris Anderson onlinelibrary.wiley.com/doi/full/10.11…

Marios Georgakis Dipender Gill Jonathan Rosand MD MSc Chirantan Banerjee Chris Anderson MUSC Neurology Thank you Marios!

#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals ahajournals.org/doi/10.1161/ST…

Among the things hospitals teach you is a deep respect for disease. It is really hard to move the needle. We won't "cure all disease in 10 years". And there's a good change that medicine will still look much the same a decade from now.