Lovely, but what does this tell us about mechanism? #Reject

Many years of great coop with Schotta lab on pioneer transcription factor Foxa2 function in stem cell-derived endoderm development finally online: biorxiv.org/content/10.110… Conclusion: Foxa2 is directed by chromatin environment and coop TF binding to targets for chromatin opening.

Our latest study on how ISWI and SWI/SNF differentially regulate TF binding and chromatin structure in mouse ESCs is finally out: nature.com/articles/s4158…

Preprint of our #CDlab &HaeringLab on DNA loop extrusion by SMCs biorxiv.org/content/10.110… Many surprises here: - Loops can mutually exchange size - Condensins can pass one another! - to form totally new type of ‘Z’ loops - that may fill DNA gaps

PREPRINT ALERT! CRISPR activation coupled to single cell sequencing reveals exciting new regulators of zygotic genome activation, including Dppa2 and Smarca5. Congrats Celia Alda-Catalinas @meleckmas @OanaKubinyecz Danila Oliver Stegle et al! 🎉 #CRISPR #singlecell #epigenetics

In our latest work with @ryanlisterlab published today NatureEcoEvo, we found that a sponge has a hypermethylated genome very similar to those of vertebrates and unlike any other invertebrate, suggesting independent evolution in so disparate lineages: nature.com/articles/s4155… 1/7

20 years after Okano's original Dnmt3b KO mice, at last the much needed catalytically inactive version has been made. And of course, it's not just about DNA methylation. Looking forward to reading this one. rdcu.be/bSAoX

Genetic conflict and DNMTs. What's not to love?

This 1% DMSO trick really works wonders for #CRISPR knock-ins. The paper below describes it for the non-coding regions of the #genome, but we've also been getting ORF knock-in rates at >1 out of 12 clones with HT-29 cells! #GenomeEditing #AcademicTwitter journals.plos.org/plosone/articl…

Excited to announce something very meta – a paper on bioRxiv about bioRxiv! 1/n biorxiv.org/content/10.110…

iPSCs (or iPSC derived Cardiomyocytes) in space! A Mel Brook's movie? "Transcriptomes in space" - around 1000 genes altered as a result of low gravity...enriched in mitocondrial/metabolic terms. One wonders how the passaged these cells! cell.com/stem-cell-repo…

This is a game changing tech in the quest to finally get a grip on understanding the roles of long repeat variation and its epigenetic modification in transcription, genome structure and disease! @PayGiesselmann Oxford Nanopore MPI for Molecular Genetics

Single-cell profiling of DNA methylation + Transcription + Chromatin accessibility in gastrulating embryos (😵). Tour de force from Reik Lab MarioniLab & Stegle Lab. First on bioRxiv now at @nature nature.com/articles/s4158…

Been waiting for these sorts of experiments! Important when considering validation rates for enhancer and promoter elements (needs to be relative to background expectation).

We not only show that The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme, but also that the genomic patterns of DNA methylation are largely guided by the intrinsic specificity of DNMT3A and DNMT3B, particularly repetitive elements academic.oup.com/nar/advance-ar…

Thanks to rapid global data sharing of #SARSCoV2 genomic data via gisaid.org, we can reconstruct large and small scale patterns of #COVID19 spread. This is a thread discussing this intersection of large and small. 1/7

Ever wondered why we have a South American opossum collection here in London? Find out about our exciting work using this cool evolutionary model... 🧬🔬

A human monoclonal 1 antibody blocking SARS-CoV-2 infection biorxiv.org/cgi/content/sh… #bioRxiv

Really cool paper about de novo DNA methylation right after fertilization. The kicker: mom's DNMT3A methylates dad's DNA, controlling paternal expression. (i'm also slightly biased bc Julien Albert—the first author—will be my post-doc!) biorxiv.org/content/10.110…