Most viewed in the last 7 days from JAMA Neurology: β-blocker use was associated with delayed motor onset in preHD and reduced the rate of worsening of symptoms in mmHD. ja.ma/3P5plHJ

There's a new kind of coding I call "vibe coding", where you fully give in to the vibes, embrace exponentials, and forget that the code even exists. It's possible because the LLMs (e.g. Cursor Composer w Sonnet) are getting too good. Also I just talk to Composer with SuperWhisper

Reversible opening of blood-brain barrier is here. NEJM study showed that low-intensity focused ultrasound can temporarily open the blood-brain barrier to augment antibody-based removal of amyloid plaque in patients with Alzheimer’s disease by up to 63%. nejm.org/doi/full/10.10…

Averaging brain responses is not really a great idea... #neuroscience doi.org/10.1038/s41467…

Why academia is sleepwalking into self-destruction. My editorial Brain If you agree with the sentiments please RT. It's important for all our sakes to stop the madness academic.oup.com/brain/issue/14…

Wow. I cannot believe it. Just asked Claude to make the dogfight ultra realist! ✅ hit impacts ✅ smoke when damaged ✅ explosion on death ✅ free-fall with smoke It feels so good to fly! + awesome plane and controls, 100% in Cursor with 0 code edition from me. LOOK AT THIS!

Compare this ridiculous example with statements on ~40% of dementia can be prevented by changing lifestyle factors. This fact seems almost universally accepted by the dementia field, but RCTs are not so convincing (almost all negative).

Clinical research in the UK is under threat, partly because it takes so long to get a study or trial approved. Here are some of my suggested solutions in this BMJ Opinion piece NIHR Wellcome UK Research and Innovation bmj.com/content/388/bm…

Great to be at the DPUK Translation Conference 2025 #translation2025

Some people today are discouraging others from learning programming on the grounds AI will automate it. This advice will be seen as some of the worst career advice ever given. I disagree with the Turing Award and Nobel prize winner who wrote, “It is far more likely that the

New *Funded PhD opportunity* for UK students to work with me at UCL (London), researching auditory training interventions to improve speech understanding in noisy environments. Deadline 28th April. Full details: bit.ly/4ccbbzj SHaPS UCL Psych & Lang Sci [please RT]

At University of Oxford it's time for the staff survey. Here's my answer to: "What is the main thing the University could do to help you to progress your career?" Please RT and respond similarly to the survey if you agree. It's the only way to get our points across!

Today NEJM Challenging dogma for routine surveillance imaging after cancer treatment The results of 12 randomized trials show no survival benefit, despite scans leading to more chemotherapy, surgery and radiation nejm.org/doi/full/10.10…

Manohar et al. show that wearable sensors tracking everyday movements combined with machine learning models can accurately capture symptoms and disease progression in cerebellar ataxias. tinyurl.com/mu6ffchn

👀Using an autonomous agent based on o3-mini and GPT-4.1, a team from Harvard, MIT & other institutions reproduced and updated an entire issue of Cochrane Reviews in two days… saving 12 person-years of work! The AI reviews captured more papers & were more accurate than humans.

NPTX2 is emerging as a key neurodegeneration biomarker, but measurement tools are limited. We developed a low-volume, automated Simoa assay for its quantification in CSF #biomarkers #neurodegeneration pubmed.ncbi.nlm.nih.gov/40522075/

We are hiring a substantive consultant neurologist to join our fantastic regional MND service. Please get in touch through the advert if you are interested jobs.nhs.uk/candidate/joba…

Chocolate consumption enhances cognitive function. There is powerful correlation between chocolate intake & the number of Nobel Prize recipients.

Recursion! I gave ChatGPT Agent access to my ChatGPT by logging in and then...

Promising results at #AAIC25 from US case report on use of #lecanemab 2-years post-FDA approval, 84% of patients were stable or showed improvement #dementiaresearch #beginningoftheend