It isn't simply #stimulate, stimulate, stimulate,... prior #immunity dictates #infection #risk, but also quality of the #antibody #response, #antigenic #breadth of how much you can be #boosted

A #HKUSPH & The University of Chicago research on childhood immune imprinting studied data in Hong Kong and finds: ▪those imprinted to H1N1/H2N2 ➡17% lower risk of getting H1N1 ▪if imprinted to H3N2 ➡12% lower risk Tim Tsang Sarah Cobey Ben Cowling Journal of Infectious Diseases:bit.ly/3Xvml9M

A #HKUSPH research observes high mortality during the Omicron BA.2 wave in Hong Kong due to lower vaccine coverage (42%) among adults ≥65 years old. ⬆ in antiviral usage & vaccination uptake over time in 2022 was associated with ⬇ case fatality risks. medrxiv.org/content/10.110…

our Cobovax study observed similar incidences of omicron BA.2 infection across diff vaccination groups despite weak neutralising antibodies to BA.2 in 3rd-dose CoronaVac recipients, suggesting nAbs may not be appropriate correlates of protection for inactivated COVID-19 vaccines

How should we interpret recent patterns of SARS-CoV-2 evolution, from EG.5 to the new BA.2 descendent? What can we learn from other viruses? And where might things being heading next? I discuss some of the key ideas and research: kucharski.substack.com/p/what-next-fo…

A short 🧵on a recent study by Margaret (Maggie) Lind with @MHitchingsEpi Derek Cummings Albert Ko et al. Data show that immunity induced by vaccines, prior infection or both (hybrid) protects against SARS-CoV-2 infection when viral exposure is low to moderate (1/) nature.com/articles/s4146…

Fantastic opening to our 3-day international conference this morning #immunity2023 with many excellent presentations including opening talks by Malik Peiris and Maria Van Kerkove

New preprint: Reconstructed influenza A/H3N2 infection histories reveal variation in incidence and antibody dynamics over the life course medrxiv.org/content/10.110… 1/12

Our paper on the role of antigenic space in determining dengue disease risk is out as a cover article Science Translational Medicine science.org/doi/10.1126/sc…

"The majority of immune protection against #SARSCoV2 conferred by natural infection cannot be fully explained by serum nAbs [neutralizing antibodies] alone." Varies considerably by variant nature.com/articles/s4159… Kaiyuan Sun Nature Medicine

Age and fever symptoms can help identify highly contagious influenza patients. Our research at #HKUSPH helps control and prevent flu transmission. Check it out👉🌍Original source: orientaldaily.on.cc/content/news/o…

【Latest Research】A team led by Bingyi Yang, Research Assistant Professor of #HKUSPH has revealed that neutralizing antibodies (nAbs) serve as a key immune correlate for COVID-19 vaccine protection. 🔍 Key Findings: ✔️ Neutralizing antibody (nAbs) levels and vaccine efficacy /

【Latest Research】A recent study led by Dr Bingyi Yang, Research Assistant Professor of #HKUSPH has analysed 200,000 hemagglutination inhibition (HAI) titrations from ferret models. This research reveals critical insights about influenza immune evasion. 🦠💡 🔍 Key Findings: ✔️