We have a postdoc opening to investigate mechanisms of DNA replication using (bulk and single cell) genomic. Please contact me if you are interested (institutcochin.fr/en/equipes/epi…) #epigenetics #DNAreplication

One commentary in médecine/Science (in french) medecinesciences.org/articles/medsc… that comment the characterization of a novel kind of response to replication stress that we published this year DOI: 10.1038/s41418-023-01141-0 See below the visual abstract

✨Today and tomorrow, at the Institut Jacques Monod, we sponsor the #Dingodays! Organized by V Geli, P Kannouche Kannouche Lab, S Lambert Lambert Lab, B Lopez Bernard Lopez, B Palancade @PalancadeLab, & P Pasero @PaseroLab ▶️dingo2023.fr/en/

Glad to give a talk to present the results of a project supported by ARTP Officiel. Looking forward to the discussions!

Very happy to share our last paper showing the induction of oxidative DNA damage by proton microbeam irradiation ! A great collaboration with Celine Baldeyron. authors.elsevier.com/a/1iFfm5aisDUB…

Very sad news. Angelos was such a nice man and thoughtful scientist. My deepest condolences to his family, friends and lab members

Using reconstitued complexes, we found that the long KER helix mediates DNA binding and stimulates pombe CAF-1 association with PCNA. Also, the WHD domain behaves differently from other species. Great collaboration with Ochsenbein Francoiz and Geneviève Almouzni. doi.org/10.7554/eLife.… eLife - the journal

Après nature, une couverture détaillée de Science Magazine des enjoux et réactions aux coupes budgétaires pour la recherche (et la transition environnementale) annoncées le 22 février. science.org/content/articl…

A funded PhD position is available in the lab to work on how nuclear architecture influences DNA repair and genome instability. If interested, please DM or apply though the doctoral school web site : doctorat.campusfrance.org/CF202434553

Only few days left to apply. Dead line is 21st March 2024.

Check out our latest projects and contact us if you like what you see and have expertise in bioinformatics, genomics or epigenetics. We are recruiting !!

We are pleased to announce the publication of our latest paper. Although this achievement comes with mixed emotions, we dedicate this work to the memory of our esteemed team leader Angelos Constantinou whose vision continue to inspire us. InstituteHumGenetics doi.org/10.1016/j.celr…

😍😍😍

Meiotic DNA break resection and recombination rely on chromatin remodeler Fun30 biorxiv.org/content/10.110…

please find my novel address: @Bernard-S-Lopez.bsky.social

The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability. (A new role for the oncogene AKT1: the phosphorylation of MRE11). academic.oup.com/nar/article-ab…

The LoL-DDR (doi.org/10.1038/s41418…) is dysregulated in transformed cell lines (doi.org/10.1038/s41598…)

Specific Low/Endogenous Replication Stress Response Protects Genomic Stability via Controlled ROS Production in an Adaptive Way and Is Dysregulated in Transformed Cells mdpi.com/3429566 #mdpicells via Cells MDPI

Plot twist: homologous recombination actually promotes the development of cancer! This discussion has been started in the hope that it will be useful, see the link: doi.org/10.1038/s41388…