iSGLT2 in stage 5 CKD: never to late to start? acpjournals.org/doi/10.7326/M2…

Paradigm shift for minimal change disease #MCD management?

Two recent reviews of #ANCA vasculitis with wonderful graphics, and for the first time I think, #PR3 🔹 and #MPO 🔸 phenotypes are considered in parallel but SEPARATELY! A new era with individualized treatment is coming for sure!
🔹doi.org/10.1016/s2665-…
🔸doi.org/10.1016/s2665-…

My take:
for detailed pathogenesis, read the #MPO 🔸review
for detailed emerging therapies, read the #PR3 🔹review
🔸doi.org/10.1016/s2665-…
🔹doi.org/10.1016/s2665-…

A new era is coming for auto-immune/inflammatory diseases: hopefully soon enough we will be able to get the anti-inflammatory effects of glucocorticoids without the adverse side effects 🔥 (see the nature paper nicely explained below)

Glucocorticoids (GC), like dexamethasone and prednisolone, are widely used in medicine, but how do they actually work?

This is really impressive work (Auger et al.), which figured it all out

There are two mechanisms: a slow, broad response, which depends on transcriptional…

🆕 Nouvelle #WebconfFAI2R pour vos patients : Nous retrouvons le Pr Alexandre KARRAS pour une nouvelle vidéo sur la #vascularite à anticorps anti-membrane basale glomérulaire 👉 fai2r.org/videotheque-pa… #Goodpasture #maladiesrares #fsmr En partenariat avec Raphaël DARBON 🤝

Bravo à tous les nouveaux PUPH et MCUPH de Néphrologie! Mehdi Maanaoui @mohamadzaidan @camillecohen Benoît Brilland Sébastien Rubin @manondekeyser Antoine Lanot @emmanuelesteve
mathieu legendre

Final criterias selected for defining #ANCA vasculitis responses: the BVAS (and its somehow difficulty to assess + lack of granularity for some acute organ damage - 👋🏻 the nephrologist in the room -) is still a major part of response assessment. Dr. S. Monti #vasculitisBCN2024

CXCR2, CCR4, CD20… specifics PET tracers have been developed and some studies already published/ongoing about their abilities to diagnose/predict active vasculitis… we need to apply this to assess kidney inflammation in #ANCA #glomerulonephritis ! Jason Tarkin #vasculitisBCN2024

What an incredible meeting it was here in Barcelona Vasculitis Workshop Barcelona #VasculitisBCN2024! See you all in 2 years in Melbourne! 🇦🇺 Kitching Laboratory Catherine Hill Vicki Quincey ANZ Vasculitis Society

Thanks Andreas!

Association between proteinuria/hematuria evolution overtime and kidney survival in #ANCA vasculitis. Too bad that proteinuria was not assessed as continuous variable: 3g/g at 12months not the same as 0.7g/g. Dr. B. Sanchez Alamo @vasculitisBCN2024

However, considering a larger (that may be discussed) composite criteria (minor relapse, major relapse, progression, death, ESKD) in favor of standard GC dose, especially for RTX patients and severe AKI #vasculitisBCN2024 2/2

Reduced GC dose in #ANCA vasculitis: Benjamin Terrier confirm results from PEXIVAS in real life cohort study, ie no difference in the composite outcome of death/ESKD. 1/2

Outcomes of kidney transplantation in #ANCA vasculitis children: tremendous amount of work carried by Dr. G. Trivioli #vasculitisBCN2024 . Important role of the ANCA status at the time of KT.

What do clinician researchers need most? Money & time. Maxime Samson main keys to success for pursuing an academic career in vasculitis: find a good mentor, stay focused, keep in touch with patients and work together 🤜🏻🤛🏻 (and money, and time) #vasculitisBCN2024

Early identification of patients at risk of renal flares in ANCA vasculitis is crucial. This study concluded that urinary CD4+ T-cell counts could identify patients with ANCA-associated vasculitis at a substantial risk of renal relapse within 6 months bit.ly/JASN0311

New model of murine #ANCA associated vasculitis: optimization of the immune stimuli used allows to cover more phenotype of the #AAV disease. Dr. C. Jennette #vasculitisBCN2024

Questions remaining:
▶️ anti MPO specific CAR-T cells instead of CD19 CAR-T cells ? To preserve the regulatory fraction of B cells
▶️ how long will the effect last? ie which time point for next injection / RTX relay ?
#vasculitisBCN2024