🔥🔥Hot off the press ! CAZymes power💪💪 #Glycotime So glad and honored I contributed to the study of this new class of enzymes ! Congrats to the whole team, especially to first author Clelton A. Santos and to project leader Mario Murakami - Structural Enzymology nature.com/articles/s4158…

Great thread on "useless science"! 👇

NEW: The world's leading protein design lab is at it again David Baker's lab newest publication in Science is on making enzymes from scratch with AI Future uses range from more precise gene-editing enzymes to proteases that hit more targets: endpts.com/david-baker-la…

New research shows that microtubule plus-end tracking proteins (+TIPs) self-organize into fluid fractal networks! These structures help position the nucleus for cell division—combining flexibility with strength. 📖 Read more: brnw.ch/21wQH8B #ResearchAtPSI

Finally on Bluesky! Looking forward to reconnecting with friends and colleagues who’ve moved from Twitter or planning to do so. You can find me there at Basavraj khanppnavar.bsky.social See you soon! #Bluesky

Our work on reversible anticoagulant was featured on the cover of Nature Biotechnology.  If you are curious about the technology here is an accessible podcast from the W-lab science talk - Anticoagulants that can be reversed, if need be: creators.spotify.com/pod/show/w-lab…

We are depositing the following mice to Mutant Mouse Resource & Research Centers Adgrf5-EGFP-CT-IRES-CRE GPR123- EGFP-CT-IRES-CRE GPR124- EGFP-CT-IRES-CRE GPR125- EGFP-CT-IRES-CRE Gpr133-EGFP-CT-IRES-CRE GPR156-IRES-Cre GPR156-mGL-IRES-Cre GPR75-IRES-Cre Bai1 mGL-CT-IRES-Cre GPRC5A- EGFP-CT-IRES-ERT2-CRE 1/2

Molecular-dynamics simulations of seven selected ligands of the ACDC domain of Plasmidium ApiAP2 provide a new molecular basis for the future design of ACDC inhibitors doi.org/10.1107/S20597…

🚨New paper out! 🚨 The apicoplast is an essential plastid retaining many crucial metabolic pathways 🦠🏭 However, bypassing all of them makes the apicoplast dispensable! nature.com/articles/s4146…

Fantastic work by our collaborators and colleagues who decipher the role of apicoplast in Toxoplasma gondii.

Very excited to announce that I have moved across the pond to start my new position as Assistant Director for Chemoproteomics @ the Nucleus Sarafan ChEM-H. This position allows me to do what I love: fun science, collaborations & teaching everyone about the wonders of #masspec 🥳

Male blue-lined octopuses inject females with venom during mating to avoid being eaten by their partners go.nature.com/4kL1ETC

Happy to share our latest publication on NatureStructMolBiol Natural Structure & Molecular Biology, we show tau filaments show Alzheimer fold in mutants V337M and R406W. nature.com/articles/s4159… nature.com/articles/s4159… thanks Sjors Scheres and Michel Goedert support 🥳🥳🥳

Many thanks Biopatrika for this opportunity and sharing our findings on #Botox.

Our investigation of lipid dependence of Cx32 gap junction channel conformations is now online on bioRxiv. Great work by Pia Lavriha, Carina Fluri and Jorge Hernández González! biorxiv.org/content/10.110…

Check out our new study revealing how ATP-independent activator Bpa binds asymmetrically to the Mtb #proteasome — and pinpointing key Bpa residues involved in substrate interaction. 👏 Tatjana v. Rosen Rafał Zdanowicz @yasserelhadeg 🔗nature.com/articles/s4146…

Happy to share our recent work in Nucleic Acids Res doi.org/10.1093/nar/gk…. We unravel the mechanism of deamination of Mycobacterium enzyme that selects for mutagenic bases, protecting Mtb from triazines. Kudos to Rajarshi Chakrabarti and Anand Lab for their collaborative efforts.

I am delighted to share our findings on the binding mode of tetanus neurotoxin and the anti-epileptic drug Levetiracetam to SV2A, an essential synaptic vesicle membrane protein of unknown function, now online in Nature Communications   nature.com/articles/s4146…

The elusive mechanism by which ATP is translocated into the ER in exchange for ADP has been revealed by a fantastic paper by my colleagues in the David Drew lab! Congratulations to all who contributed in this amazing well rounded study! nature.com/articles/s4158…

Structure-guided engineering of snake toxins for selective modulation of adrenergic and muscarinic receptors nature.com/articles/s4146…