Genetic & molecular mechanisms – inc. control of #alternativesplicing – regulating development of #muscle revealed in #drosophila . Image & research by Elena Nikonova et al Spletter lab Universität München in PLOS Biology. Article link & BIG searchable archive on bpod.org.uk/archive/2024/5…

Microscopy from our recent publication was highlighted by biomedical picture of the day!
Check it out and along with other interesting images on their website: bpod.org.uk/archive/2024/5…

#Endothelium bearing the #mutation initiates the #lung pathology in patients with mutated STING gene –potential treatment target. Image & research by ImmunoKevin et al Kate Fitzgerald & Ann Rothstein labs UMass Chan Medical School in Cell Reports. Link & vast archive on bpod.org.uk/archive/2024/5…

Blik, a new user-friendly, open-source tool for annotation & analysis of #cryoET data - plug-in to #pythonprogramming software image viewer #napari . Image & research by Lorenzo Gaifas et al Université Grenoble Alpes in PLOS Biology. Article link & massive BPoD archive on bpod.org.uk/archive/2024/5…

Novel mouse model of #Duchennemusculardystrophy #DMD that has variation in #immuneresponse & effects on #muscle , as in humans. Image & research by Kristy Swiderski et al Gordon Lynch lab University of Melbourne in DMM Journal. Article link & massive BPoD archive on bpod.org.uk/archive/2024/5…

Image processing pipeline in #RELION 5 for #cryoET reconstructions unprocessed => high-res model, aiding standardisation & cryoET newcomers. Image & research by Alister Burt & Bogdan Toader et al Sjors Scheres lab MRC Laboratory of Molecular Biology in bioRxiv. Links on bpod.org.uk/archive/2024/5…

BPoD Centro de Biología Molecular Severo Ochoa Development Glad that an image from our work recently published in Development has been selected as picture of the day. If you are interested in morphogenesis, please read or paper.

journals.biologists.com/dev/article/15…

Leg folds of #drosophila model for studying how mechanical forces from cell proliferation co-ordinate with #NOTCHpathway to shape developing epithelium. Image & research by Alonso Rodríguez et al Carlos Estella lab Centro de Biología Molecular Severo Ochoa in Development. On bpod.org.uk/archive/2024/5…

New with Tags: Novel high-throughput way of tagging #genes without perturbing protein production called HITAG. Image & research by Joonwon Kim et al Columbia Pathology in Science Advances. Article link and image licence info on bpod.org.uk/archive/2024/5…

#VR -trained deep-learning pipeline #DELiVR maps neuronal activity in cleared brain tissue. #neuroscience . Video & research by Doris Kaltenecker, Rami Al-Maskari, Moritz Negwer et al Helmholtz Munich | @HelmholtzMunich Universität München in Nature Methods. On bpod.org.uk/archive/2024/5…

Faulty Photocopies: Rhodopsin #gene duplication newly-identified genetic fault underlying cases of #vision -degenerating disease #retinitispigmentosa and modelling in an #organoid . Image & research by Sangeetha Kandoi et al University of California in eLife - the journal. On bpod.org.uk/archive/2024/5…

#Mitochondria fusing in newly developing #neurons in adulthood plays a key role in synaptic plasticity #neuroscience . Image & research by Sandra M.V. Kochan et al Bergami Lab CECAD Cologne in Neuron. Links & image licence info on bpod.org.uk/archive/2024/5…

Stretchy Needle Work: Customisable microneedle electrode array senses electrical signals in muscle with potential applications such as targeted drug delivery. Image & research by Qinai Zhao et al Hangbo Zhao lab USC Aerospace and Mechanical Engineering in Science Advances. On bpod.org.uk/archive/2024/5…

Beautiful image of a paper on Runx1 & HSCs in Nature Communications from the lab of Dr Mihaela Crisan Centre for Regenerative Medicine, the co-Director of the EdinRegenMedRepair MScR programme Institute for Regeneration and Repair.
Highlighted by BPoD as one of your daily recommended biomedical imagery dose. 🔬🧫

Tracking emergent #colon tumours in real-time at the single-cell level over several weeks in a 3D lab-grown #organoid system. Video & research by L. Francisco Lorenzo Martín Tania Hübscher et al Matthias Lutolf EPFL in nature. On bpod.org.uk/archive/2024/5…

Tubuloids - long-term expanding human organoids – model complexity of the kidney for renal function studies in health and disease. Image & resdearch by Fjodor A. Yousef Yengej et al The Clevers Lab Hubrecht Institute UMC Utrecht in Cell Reports. On bpod.org.uk/archive/2024/5…

Dynamics of transient progenitor cell populations in a mouse stem cell-derived embryoid as a model of #embryodevelopment . Image & research by Adriano Bolondi, PhD, Benjamin K. Law et al MPI for Molecular Genetics Princeton MolBio in Developmental Cell. On bpod.org.uk/archive/2024/5…

Effects of mechanical forces & shape changes at the cell level in small #intestine – different effects depending on if situated in villi or crypts. Image & research by Taylor Hinnant, Wenxiu Ning & Terry Lechler Duke Health in PLOS Genetics. On bpod.org.uk/archive/2024/5…

Structure, development, interactions & surrounding environment of microvilli-like calyceal processes on #photoreceptor cells of the retina #zebrafish . Image & research by Maria Sharkova et al University of Alberta in J Cell Science. On bpod.org.uk/archive/2024/5…

In the Basement: #Transcriptionfactor #OCT4 plays a key role in controlling #basementmembrane development – study using human post-implantation amniotic sac embryoid. Image & research by Margit Rosner & Markus Hengstschläger @MediUni_Wien in Developmental Cell. On bpod.org.uk/archive/2024/5…