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“Zombie”-making Fungus Carries an Enormous Genome @[email protected] Jason Stajich Dr. Brian Lovett Rachelle Gaudet @harvard UC Riverside Agricultural Research Service mcb.harvard.edu/department/new…

💫NEW: Chris Chidley, Sorger & co report a #CRISPR interference/activation #screening platform to systematically interrogate the contribution of nutrient #transporters to support #CancerCell proliferation in environments of variable composition. nature.com/articles/s4155…

I'm truly honored that the work on my group in Chromosome Biophysics has been so highly recognized. Particularly touched to receive this prize from Tel-Aviv University in Israel. Particularly now - in these difficult times. Honored to share this award with cees dekker, wish

Really interesting work showing that REX elements, without enhancer activity, can extend the range of enhancers if placed near them. Appears to be mediated by LIM-Homeodomain TFs such as LHX-factors.

Beautiful study questioning -among others- many established notions for mitotic chromatin organization and the role of HP proteins driving compartmentalization. Genome folding principles uncovered in condensin-depleted mitotic chromosomes | Nature Genetics nature.com/articles/s4158…

Congratulations to Andi and colleagues for systematically dissecting the actions of Condensin and Cohesin loop extruders during mitotic exit! Thanks to our long standing collaboration with the lab of Jan-Michael Peters, as well as imaging infrastructure @EMBL and EMBL Imaging Centre

Online Now: An autoinhibitory switch of the LSD1 disordered region controls enhancer silencing dlvr.it/T8B4pm

Excited to share Sarah's new review on BiDirectional Promoters (BDPs). Sarah discusses 6 molecular mechanisms that may account for unique transcriptional properties of BDP with a focus on noise regulation and co-expression: authors.elsevier.com/a/1jI5c,LqArU0…

We are thrilled to welcome Dr. Alicia Darnell Alicia Darnell and Dr. Christopher Chidley Chris Chidley as our newest Assistant Professors 👋. pcb.duke.edu/news/pcb-appoi…

Super excited to start a new chapter at MIT Dept of BE with the ASHansen Lab!

TAD boundaries are permeable, with varying efficiencies to block loop extrusion. With Li-Hsin Chang we hypothesize that this permeability can used as a DNA-encoded regulatory feature and we discuss its potential impact on genome functions. Open Access at onlinelibrary.wiley.com/doi/10.1002/bi…

So happy and relieved that this is now out in nature.com/articles/s4155…! Thanks to all authors esp Tri, Sarah H. Shahmoradian for help w revisions, and mentors Barmada Lab, Sam Pappas, and Bill Dauer for continued support. Also thanks to the reviewers who had thoughtful suggestions.

Really enjoyed reading this fantastic paper: biorxiv.org/content/10.110…

Excited about our first (of many!) collaborative endeavor with Mo Khalil out in Developmental Cell! A genetic approach to trigger heterochromatin misregulation on-demand in S.pombe enabled us to trace epigenetic adaptation in long-term, continuous cultures. authors.elsevier.com/a/1jWzg5Sx5gxl…

Factors that determine cell type–specific CTCF binding in health and d... sciencedirect.com/science/articl…

Loved the preprint version - looking forward to reading the published version.

Congrats to Nicholas Aboreden blobellab with RCMC contribution from Viraat Goel ASHansen Lab . Having recently worked on what we thought was a looping factor (ZNF143 biorxiv.org/content/10.110… ) it was amazing to work on a strong Enh-Promoter looping factor LDB1 biorxiv.org/content/10.110…

Congrats to Gavin Schlissel Pulin Li with single-molecule imaging contribution from Domenic Narducci ASHansen Lab Single-molecule imaging of hedgehog in morphogen gradients reveals a surprisingly complex diffusion mechanism: pnas.org/doi/10.1073/pn…