Systemic AL Amyloidosis in Patients Younger Than 40 Years of Age: Clin... sciencedirect.com/science/articl…

Amyloidosis, a systemic disease that manifests in various ways, should be in the differential diagnosis of unexplained proteinuria, restrictive cardiomyopathy, peripheral and autonomic neuropathy, and hepatomegaly. Treatments are improving. Full review: nej.md/4eHjGU3

This is an EXCELLENT summary of Alnylam Pharmaceuticals huge news today about vutisiran. It’s a big deal and exciting to have this one step closer for patients. Thanks for these important insights Ronald Witteles !

Great summary of major ATTR #amyloid news

#RareDisease #ClinicalTrials pose numerous hurdles–from small patient populations to limited diagnostic tools, to a lack of disease understanding. Learn how we overcome these obstacles and propel innovation forward in rare disease R&D. spr.ly/6019YuNkb

Patient Educator Ozzie educating 1st and 2nd year students at Midwestern University / Chicago College of Osteopathic Medicine. Between in-person and remote students, there were over 400 future physicians learning about amyloidosis! Many thanks to Dr. George Borrelli, course

She makes an excellent point re: how curriculums structured around organ systems might not give full insights into the awareness and diagnosis of multi-system diseases. #meded #MedTwitter

In the latest Cardiac Wire, we discuss… 🫀Alnylam Pharmaceuticals’s Vutrisiran Shines in HELIOS-B Trial 🫀2024 ESC Hypertension Guidelines 🫀DynamX’s Real World Advantages And more #cardiology news. Check it out below. #CardioTwitter #MedTwitter cardiacwire.com/newsletter/vut…

Collaborative effort - 697 patients; treated with SCT for AL amyloidosis, 3-year RRT rate 3%, 10% and 37% for renal stage I, II and III. Long-term outcomes of renal AL amyloidosis patients undergoing autologous stem cell transplantation: Validating the… pubmed.ncbi.nlm.nih.gov/39207186/

As the awareness increases of this disease, no doubt there will be more younger patients diagnosed. Per Vaishali Sanchorawala an early diagnosis is super critical to a durable and multiple decades long life.

youtube.com/watch?v=mdlJ9k… While both AL Amyloidosis and Multiple Myeloma are plasma cell disorders and share similar patient care treatments, they diverge in pathogenic mechanisms. In this presentation, Dr. Giada Bianchi from Brigham & Women’s Amyloidosis Program shares that

Here, we have summarized the structures of the systemic amyloid fibrils revealed by cryo-EM to date :) taylorfrancis.com/chapters/edit/… Shumaila Afrin Binh A. Nguyen Lorena Saelices Gomez - she/her/hers/ella

#DYK that low levels of serum TTR in ATTR-CM is an indicator of destabilization of TTR, which is correlated with earlier disease onset and increased severity? We're proud to be advancing research for the unmet needs of ATTR-CM patients.

Aaron Goodman - “Papa Heme” Unless it’s #amyloidosis….then unfortuately you’re pretty much just an average patient trying to figure out what the heck is going on with your body. pubmed.ncbi.nlm.nih.gov/26498944/

A real treat to have Ronald Witteles here with us at #ASNC2024 to present the results of HELIOS-B #CVNuc Alnylam Pharmaceuticals

On the heels of a stellar and eventful #ESC where #amyloid featured prominently, our #ATTR #FinalFour Young Investigators have been decided! Official announcement coming TOMORROW! Ahmad Masri Amyloidosis Speakers Bureau Amyloidosis Research Consortium

Love standing room only!

Did you know? mm713.org/expert-insight… It has been long believed that amyloidosis did not cross the blood brain barrier; however, evidence is showing otherwise. In addition, while most of the transthyretin protein originates in the liver, local production is found in other areas

Amyloid cases session at #ASNC2024 🎯 Key point: any myocardial uptake of PYP/HMDP/DPD on SPECT is a positive study and must be explained!

A short🧵on FISH in AL #Amyloidosis and findings of our multicenter study on 283 patients with AL treated with daratumumab-based frontline therapy (Dara-VCd/Dara-Vd) Blood Journal ashpublications.org/blood/article-…