Happy to share that I was promoted to Associate Professor of Pathology & Immunology with tenure and am Director of a new #Immunometabolism Initiative that will explore creative ways to coalesce our energies in this field across departments @WUSTL WUSTL Immunology WashU Medicine Pathology & Immunology

ahajournals.org/doi/10.1161/CI…. Excited to share our journey of ferroptosis in PAH. Thanks to generous collaborators Jesse Williams Lab @VUMC_heart (Evan Brittain), Ty Patterson and Christopher Rhodes! Circulation Research Lillehei Heart Institute UMN DOM Research The Pulmonary Vascular Research Institute ATS PC Assembly The Pulmonary Hypertension Association Sasha Prisco, MD, PhD

Farid Kadyrov in ⁦Lavine Lab⁩ show that Hypoxia sensing in resident cardiac macrophages regulates monocyte fate specification following ischemic heart injury ⁦Nature Cardiovascular Research⁩ nature.com/articles/s4416…

In ⁦nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦Lavine Lab⁩ ⁦WashU Medicine⁩, ⁦⁦Amgen 🧪🔬🧬⁩ , and ⁦ImmunoFibHF⁩ nature.com/articles/s4158…

Looks like dietary #protein and amino acids implicated in #metabolic disease & #metabolism again. Excellent work by labs of Weiping Han and Suneng Fu in Cell Metabolism showing high protein intake fuels hepatic lipogenesis and #MASLD #steatohepatitis cell.com/cell-metabolis…

3 years ago my good friend Jonathan D. Moreno approached me about this crazy idea to fill a much needed gap in heart failure education (1/3).

Since we're talking about funding of absurd research by NIH and other federal agencies, the funded scientists: - watching flies fuck - giving rats massages - spending years digging into why jellyfish glow - tracking penguin poop from space - using horseshoe crab blood

Ali Javaheri presenting at #ConnHeart Saint Luke's Mid America Heart Institute 🫀Fasting & chemo Tx: Good 🆚 bad 🫀 Doxycycline ⤵️ heart mass 🫀 fasting animal🐁 getting chemo died & ⤵️ body weight/ 🫀⤵️ EF 🫀⤵️ LV mass in humans an issue too 🫀fasting seems toxic for chemo but what if high fat diet?

Honored to be at the Conn conference with Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 and Andrew J Sauer MD --

NIH appears to have canceled/postponed all of its study sections: these are the independent review panels that approve federal grants for health research. Such grants fund the work/salaries of more than 300k people at more than 2,500 institutions

Plasma SVEP1 Levels Predict Cardiovascular Events in Hypertrophic Cardiomyopathy Beyond Conventional Clinical Risk Models Including NT-proBNP Keitaro Akita Ali Javaheri mathew.maurer Itsuki Osawa, MD #AHAJournals ahajrnls.org/4aCVsbP

We assessed iron biomarkers in HFrEF/HFpEF; low TSAT, not ferritin, was linked to worse HF outcomes, especially in HFpEF Penn Medicine Penn Cardiology @JulioChirinosMd @DLMANN_MD Ali Javaheri Marie-Joe Dib #AHAJournals ahajrnls.org/3Q0cUO8

Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration: Immunity cell.com/immunity/fullt…

Congrats to Zhen Guo for excellent work on this editorial and great work from Medina-Hernandez and colleagues - excited for future human clinical trials to prevent AIC sciencedirect.com/science/articl… -

The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some are considering changing jobs or leaving the country. Others say them might abandon research altogether.

We thank all our Babak Razani, MD, PhD Laboratory members and many collaborators in making this happen 🤝 (Xiangyu Zhang Kratky Lab Ali Javaheri Hanrui Zhang Partha Dutta lab Straub Lab Irfan Lodhi include those with Twitter handles)

Stereotactic arrhythmia radiotherapy (STAR) treats VT by locally increasing ERP, not increasing scar burden #AHAJournals #Epeeps Patrick M Boyle Ali Javaheri @SBRTCR Brian Zenger Carmen Bergom MD PhD Julie Schwarz Stacey Rentschler Lab @ WUSTL doi.org/10.1161/CIRCEP…

medicine.washu.edu/news/strategy-… Great collaborative effort with Apte Lab WashU Medicine WashU Medicine Cardiovascular Division Zhen Guo identifying a new role for ApoM in macular degeneration

🚨Two new JACC Advances papers drop today linking SGLT2 inhibitors ↔ apolipoprotein M (ApoM) across very different settings—ambulatory HFrEF (DEFINE-HF) and acute inflammation (LPS-sepsis & COVID-19). Let’s unpack why this kidney-liver-vascular axis matters. A 🧵 1️⃣/15