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Our two methods articles: #AFM for measuring nuclear mechanics and #STORM with cluster analysis to investigate organisation of nuclear proteins, are now out! Happy to have contributed to this collection link.springer.com/book/10.1007/9…

Our paper on force-regulated nucleocytoplasmic transport is now out in Nature Cell Biology! rdcu.be/cPjUj Along with a beautiful news and views article by Stefan Petrovic and Hoelz Lab: rdcu.be/cPn7f

Three positions open in the Merkle lab! This includes a computational position related to our drug discovery work for neurodegeneration. @Postdoc_Academy Postdocs of Cambridge (PdOC) Life Science PostGrads Imperial

Our latest paper from Chris Toseland lab on Myosin VI regulation is now out Biochemical Journal Natali Fili @ShefUni_OncMet

Very excited for the first day of talks BBS meeting #BBS #Biophysics

Great opportunity @MRC_LMB

Our new #mechanobiology work showing that elevated p53 levels in striated muscle laminopathies are due to mechanically induced damage to muscle nuclei, and that increased p53 signaling is sufficient to induce muscle dysfunction, is now on bioRxiv: biorxiv.org/content/10.110…

Thanks BBS and @peter_protein for organising #BBS2022 Great conference!

Check out our latest work in Oncogene Journal showing that highly metastatic breast cancer cells have more deformable nuclei that facilitate migration through tight spaces. The reduced lamin A levels responsible for this also alter many other pathways: rdcu.be/cSugU

Today in partnership with EMBL-EBI, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: dpmd.ai/AF-22-TW 1/

What if you could pull on chromatin in a living cell to understand what that material is like? It's a similar question to the one Maxime Dahan, Antoine Coulon and Daniele Fachinetti asked me when they interviewed me for a postdoc to do just that.

Nice work Callum Ormsby Alister Burt

Our structure of dynein-dynactin on microtubules is now out in nature! Thanks to Janet Iwasa for this beautiful movie showing how cargos might use pairs of adaptors to recruit their motors. nature.com/articles/s4158…

Chromatin in the liver becomes more accessible with age. Yet, gene expression is only slightly affected. Why? Turns out it is all about polymerase pausing. Excited to see my main PhD work out in Mol Syst Biol embopress.org/doi/full/10.15…

Excited to share our latest work on the budding yeast inner kinetochore! It was great working alongside Ziguo Zhang, Jing Yang, Johannes Schwab, @LMB_Biophysics, Stanislau Yatskevich, Sjors Scheres, and David Barford on this complicated system. biorxiv.org/content/10.110…

A dad is urging people to support our petition after his family’s lives “changed in an instant” when his 10-year-old daughter was diagnosed with an inoperable diffuse intrinsic pontine glioma (DIPG) in March 2023. Read more ➡️ bit.ly/3OoayZu

Excited to see this paper finally out from my PhD with Chris Toseland @ShefUni_OncMet doi.org/10.1038/s41467… Thank you to all my co-authors and collaborators! Alice Pyne is on 🦋 Dan Eddie Rollins Marisa Martin-Fernandez Lin Wang ⬜️⬜️王璘

Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!! Check out our first lab preprint Ália dos Santos et al! biorxiv.org/content/10.110… Piotr Kolata Alister Burt TomDendooven @MRC_LMB

An excellent Peterhouse Cambridge Biology Symposium yesterday. Abstracts available in a few days at islandbiodiversity.com/petbiosymp.htm. Thanks to those who attended and all who took part including Charlotte Wright Dr Alex Tsompanidis Hugo Fleming Ália dos Santos James McCulloch @Dylan_Flicker Andrzej Wolniewicz