It could be one of the most important studies I had the privilege to contribute in my early scientific carrier. Based on these results, there is already a trial that has started some time ago (SHERPA). Hope to see the good results! fingers crossed! :)

The study is a follow up work from our previous publication based on dietrich ruess and Katrin Ciecielski `s wonderful work. You can find the great load of mind blowing data, proving the importance of SHP2 in KRAS dependent cancers in the publication: nature.com/articles/s4159…

The paper offers a wonderful tool to study NF-kB, without genetic silencing or overexpression of the transcription factors. Amazing work! Double knockin mice show NF-κB trajectories in immune signaling and aging cell.com/cell-reports/f…

Wonderful meeting/discussions with our friends from twitterless Marc Nazare and his team in Berlin FMP Berlin. Thanks to ⁦DFG public | @[email protected]⁩ great joint effort and progress on generation of new class SHP2 inhibitors. ⁦Algül Lab⁩ learnt a lot about medicinal chemistry. 👌

Great to present our progress on SHERPA trial with Bernards Laboratory@NKI at StanduptoCancer with wonderful and thoughtful remarks of the Nobel laureate Phil Sharp. So grateful to StanduptoCancer wonderful meeting with giants in the field of cancer

Remarkable talk given by Robert Winn on cancer health equity in lung cancer. Very important topic, good luck and keep going. Very relevant! Good luck!!! In a nutshell: ZNA vs DNA!! Thanks to SU2Cscience for supporting such projects

Great honor to meet with Prof. Capecchi in person, nobel laureate 2007. His work made it possible to engineer mice genetically to model diseases, including pancreatic cancer as we study it. #science #lino2023 #sciencecelebrity

Proud to share our latest work in Journal of Clinical Investigation jci.org/articles/view/…✅ Tremendous effort by our lab members with Xiabo Wang and key contributions by Algül Lab as well as great work by @gastrotum @labreichert & more! #PancreaticCancer #CancerResearch #Cancer #Demirlab

Tgfa-Ccl2-paxillin axis driving human-like neural invasion! This great study is finally out Journal of Clinical Investigation! Many congratulations to first author Xiaobo and the team of Prof. Demir, one of the pioneers in cancer neuroscience,DEMIR Lab, and Dr. Lesina from our Algül Lab!

Algül Lab is hiring a new postdoctoral researcher! If you are excited to work in the pancreatic cancer field under the funded BMBF consortium, we are looking forward to seeing your applications! Please spread the word!😊#pancreaticcancer #postdoc eacr.org/job/postdoctor…

Checkout new paper from our lab in Nature Genetics link: nature.com/articles/s4158… We mapped pancreatic cancer ecosystems across primary tumors and metastases using spatial transcriptomics on matched samples . Ateeq M. Khaliq PhD Bassel El-Rayes, MD IU Simon Comprehensive Cancer Center

Timescales in Cell Biology

Reminder: At our Translational #Gastroenterology Seminar in #Munich on Tuesday, we welcome Prof. Jacco van Rheenen (Van Rheenen Lab) from The Netherlands Cancer Institute with his lecture ‘Filming the fate of cells carrying mutations in #cancer driver genes’. Join us and learn more about his research.

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer | Nature nature.com/articles/s4158…

"Algül Lab proudly presents… 🥁 The long-overlooked child of NF-κB signaling in solid tumors: c-Rel! Our latest study shows how this underdog drives PDAC metastasis by helping cancer cells survive isolation stress. Curious about how? Sneak a peek here: doi.org/10.1101/2025.0…

Tour de force pancreas cancer study in @nature by Anirban Maitra (Anirban Maitra) MD Anderson Cancer Center, revealing profound transcriptomic heterogeneity & TME dynamics in metastases. Interesting CAF dynamics associated with cell state changes -- super cool. doi.org/10.1038/s41586…

We are looking forward to welcoming Dr. David Herrmann from Invasion and Metastasis Lab (Garvan Institute of Medical Research) to speak at our institute! He will share his recent work on targeting pancreatic cancer invasion and metastasis. July 7, 5pm - looking forward to his insights!