In attempting to prove I am not a robot repeatedly, I watched every date and time slip away.

This is part of a dangerous trend in reporting each allergic reaction as news. A million people have been vaccinated. A few had allergic reactions. All turned out fine. More will occasionally happen. They don’t all need headlines. It inaccurately skews perception of risk.

If acute mRNA COVID vaccine reactions are anti-PEG IgE or IgG and complement mediated we should see many more with booster doses. If they are direct nanoparticle complement activation from accidental IV exposure then the rate will probably be about the same with booster doses.

In this study, patients with moderate/severe CSU were randomised to receive ligelizumab 24, 72, 240 mg; omalizumab 300 mg; or placebo every 4 weeks (q4w) for 20 weeks. Follow the link to discover the result. bit.ly/3jWK5Rh #Allergists #Immunology #Clinicalimmunology

Andrew J. Rennekamp Really interesting. Is Uli on twitter?

1/ New guidelines from the US_HAEA Advisory Board are now available JACI In Practice. We provide an update on classification, diagnosis, on-demand/prophylactic tx with special considerations for women/children along with guidance on development of a comprehensive management plan.

Our FAQ on allergy concerns & #COVID19 vaccines is fully updated. With: new details on rare anaphylactic reactions to date; CDC on lack of 'pattern'; answers to Qs on specific allergens; PEG issue ++. Special thanks to #allergy team at MassGeneral News Kimberly Blumenthal, MD, MSc

Can’t wait to geek out over allergic immune responses with PoholekLab and @rod_rahimi - join us on Jan 26th at 2pm EST!

On John Hume’s 84 birthday let’s recall the words of former President Mary McAleese: “There are very few simple truths in life. But when it comes to John Hume, and his role in bringing peace to Ireland, there is one. Without him, there simply would not have been a peace process.”

"Science has been muzzled." In an exclusive interview with The Lancet, Susan Jaffe speaks to incoming CDC Director, Rochelle Walensky about the challenges and opportunities ahead and how she will restore trust at the organisation. Read the World Report: hubs.li/H0DZJyP0

To learn more about Rochelle Walensky (Rochelle Walensky, MD, MPH) read this Profile, written by Susan Jaffe (Susan Jaffe): hubs.li/H0DZ5Hc0

Wasn't Amanda Gorman’s poem just stunning? She's promised to run for president in 2036 and I for one can't wait.

Resurgence of #COVID19 in Manaus, Brazil, despite indications 76% of population previously infected by October, 2020—authors provide 4 possible explanations and stress the need to quickly investigate characteristics of #variants. Read: hubs.li/H0FBpFy0

Ester C Sabino, Nando Faria, Marcia Castro, CADDE Project

This is our warning call, America. Cases are now climbing again in a majority of states--esp across the northeast and midwest. CDC Director Walensky is right to be sounding the alarm. This is how surges start.

The complexities of Boston not for profit hospital chiefs sitting on for profit boards. The Boston Globe Spotlight Team team takes a deep dive, with a few comments from me. Over time, I changed my view to think this wasn’t a good idea - risk/benefit ratio for institution not favorable.

Dr. Mayer proposes a radical paradigm shift: that the gut microbiome is at the center of virtually every disease that defines our 21st-century public health crisis.

Asthma, a chronic inflammatory disease of the airways, is increasing in prevalence. Dr. Aidan Long MD from MGH Rheumatology discusses treatment approaches and updates for managing asthma. #PCCM2021

Last evening in Kigali, President Kagame and First Lady Jeannette Kagame joined Didi Bertrand Farmer and family as well as friends and colleagues of Dr. Paul Farmer for a farewell ceremony in honor of Dr. Paul Farmer and the immeasurable global impact of his life.

Few patients are eligible for severe asthma biological trials. Reassuring that our systematic review of real-world data confirms that they deliver significant improvements in asthma control, exacerbations & lung function. Improvement comparable to RCTs. doi.org/10.1111/cea.14…