A study analyzed cytomegalovirus (CMV) reactivation in patients undergoing #HSCT and found risk factors for reactivation were CMV seropositivity, haploidentical HSCT, older patient, and grade II-IV acute #GVHD . ow.ly/TC8w50RNTct

A study examined ruxolitinib pharmacokinetics and pharmacodynamics in children with acute and chronic #GVHD . Results show that their proposed ruxolitinib dosing schedule can be adopted for children age >2 years and weighing >10 kg. ow.ly/OFBN50RNTbN

A study compared outcomes of FM80 and FM140 in #mdssm patients undergoing #alloHCT and found the FM140 group showed significantly higher 3-year overall survival rate. Study suggests the superiority of FM140 in patients with #mdssm undergoing #alloHCT . ow.ly/xMBK50RNT59

This Reflections article from the May issue of the ASTCT Journal puts a spotlight on Robert A. Good, who is often referred to as the founder of modern immunology. Click to read more about his pioneering work in #immunotherapy . ow.ly/ejNS50RNT29

New study in ASTCT journal investigates the incidence of fertility potential and gonadal function impairment in young adult survivors of #HCT and to identify risk factors. Study findings share impact for both young male and female transplant survivors. ow.ly/VGW950REMOb

A study in the ASTCT journal reveals that results of umbilical cord blood transplantation in patients with Fanconi anemia have improved. It further suggests that follow-ups and life-long screenings are crucial for survivors of #HCT for Fanconi anemia. ow.ly/3utA50REMgs

The ASTCT International Affairs Committee publishes a report on the 4th Workshop on Quality as a Development Tool for Hematopoietic Cell Transplantation Programs which took place at #Tandem23 . Read the full report in the May issue: ow.ly/a0vX50REM93 #HCT #BMTsm

A retrospective registry study comparing the effect of fludarabine (Flu) doses suggests that high-dose Flu was associated with favorable outcomes in the Flu and busulfan group but not in the Flu with Melphalan group. ow.ly/ybkB50REM5l

A study on clinical outcomes and toxicity in older adults (75+) receiving #CARTcell therapy underscores age alone is not a contradiction for CAR-T and found encouraging rates of overall survival across age categories. ow.ly/roq250RELZC

New research reveals lactose linked to Enterococcus growth, impacting #GVHD in cellular therapy recipients. A lactose-free diet slashes VRE carriers by 16%, offering nonantibiotic strategy for high-risk units. Read more: ow.ly/pRs650RxYjY

This study demonstrates that N2MBW is a more feasible test compared with spirometry in children post #HSCT . However, in an exploratory analysis, lung clearance index did not lead to earlier detection of BOS when compared to spirometry. Red more: ow.ly/6Ajm50RxYic

A 10-year study examining #cGVHD durability and immune reconstitution reveals sustained reduction in cGVHD rate and lasting B cell changes post #HCT Rituximab prophylaxis, with altered subset composition and decreased alloantibody formation. Vanessa Kennedy ow.ly/wT2850RxXAs

In a cohort of reduced intensity conditioning, T cell depleted #hematopoietic progenitor cell transplantation patients findings indicate that KIR2DL1*003 positive grafts are detrimental for both 5-year disease-free survival and relapse incidence. ow.ly/rfOZ50RxXov

The May issue of 'Transplantation and Cellular Therapy,' is now available online: astctjournal.org/current
Elsevier Hematology

A new MAGIC Integrated model incorporates acute GVHD grade at both onset and D14, providing more than a nuanced advancement. If validated in future studies, this new model could reshape the landscape of clinical trials and therapeutic decisions in #aGVHD . ow.ly/Nt7650Rr3bB

A study highlights that our current practice does not adequately identify which older patients are high-risk for death after #HCT . Using frailty status, age, KPS and DRI together may allow us to inform our older patients of their chance at survival. ow.ly/ReuR50Rr30n

Research reveals diverse histologies in post-CBT intestinal failure demand tailored management, impacting outcomes. Non- #GVHD enterocolitis etiology needs clarification. Read more: ow.ly/RwYj50Rr2Mz

This study focused on caregivers of patients undergoing #CAR -T and examined QoL and psychological distress prior and post CAR-T. A major proportion of caregivers experienced psychological distress, highlighting the need for supportive care interventions. ow.ly/7vLR50Rr2y9

With #HCT procedures on the rise, it's crucial to address long-term complications. This review provides updated pediatric and adult survivorship guidelines for #HCT and cellular therapy. Read more: ow.ly/3zxh50Rr2oQ

New Study finds #AlloHCT recipients experienced more xerostomia than autologous HCT recipients, a difference that cannot be explained by a reduction in stimulated salivary flow rate or the development of oral mucosal changes related to cGVHD. Read more:
ow.ly/EfSk50Rka1H