New publication co-authored by Steven Smith in ASCPT Alexandria Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazi… pubmed.ncbi.nlm.nih.gov/38747311/cle UF Pharmacy

ASCPT Alexandria recently conducted a survey and brought together an expert panel to look at ways to move the #OncologyDoseOptimization needle. Published in CPT: Pharmacometrics & Systems Pharmacology (PSP): ➡ bit.ly/3WZHEDA | #DrugDevelopment

New #CPIC guidelines for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes, and Beta-Blocker Therapy ascpt.onlinelibrary.wiley.com/doi/10.1002/cp…

Check it out in #CPTjournal:

In ASCPT Alexandria authors consider the need for a #regulatory paradigm shift in the "age of #calamity" - engaging with CEPI Richard Hatchett lecture on the topic. #vaccinenation #vaccine #globalhealth #pandemic #crisis #science vaccinenation.org/global-health/…

We're sending a big congratulations to Clinical Pharmacology & Therapeutics on a fantastic year and thank you to everyone who contributed! ASCPT Alexandria 📷Impact factor: 6.3 📷Full text views: 1,372,502 📷CiteScore 2023: 12.7 🔗 Explore more. ow.ly/J4rk50Sz5lT

New research led by Stephanie Wang in ASCPT Alexandria reviewed the impact of priority review vouchers on medical countermeasures R&D, finding PRVs were not associated with increases in MCM development against material threats. ascpt.onlinelibrary.wiley.com/share/YGBESVDW…

We don’t think that there’s a fair equipoise between arms in Phase III trials with drugs that can be optimized with #TDM so we wrote it in this ASCPT Alexandria perspective paper. ASCPT Journal Family Pharmaco_Rennes ascpt.onlinelibrary.wiley.com/doi/10.1002/cp…

Congratulations to the 2024- 2025 Editors in Training of the #ASCPTJournal Family! @ASCPTJournals #CPTjournal #PSPjournal #CTSjournal

An adult amiodarone #PBPK model was extrapolated to the pediatric population and was able to predict the optimal dosing of amiodarone in children on #ECMO. hubs.ly/Q02N2NtG0 | #Pharmacokinetics ASCPT Alexandria

This perspective outlines major challenges in precision dosing & highlights their recent progress: 1️⃣Application in #DrugDevelopment 2️⃣Improved #ClinicalTrials 3️⃣Usefulness of response biomarkers 4️⃣Confidence in #MIPD 5️⃣Receptiveness in clinical practice ➡hubs.ly/Q02NRp740

New publication co-authored by Almut Winterstein in ASCPT Alexandria -Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry – Informing optimal antiplatelet strategies ascpt.onlinelibrary.wiley.com/doi/10.1111/ct… UF Pharmacy

New publication co-authored by Almut Winterstein in ASCPT Alexandria – Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators ascpt.onlinelibrary.wiley.com/doi/full/10.11… UF Pharmacy

Even for older drugs (like vancomycin) that have been used for decades, real-world outcomes & continued post-approval dosage optimization is the key to appropriate clinical use. hubs.ly/Q02Q0qDP0 | #PrecisionMedicine #Pharmacogenomics #PGx #GettingTheDosageRight

Latest in ASCPT Alexandria Oral 4:1 co-amoxiclav dosing provides better target coverage for clavulanic acid in neonates. Key insights into pharmacokinetics and dosing strategies! 💊👶 #Pediatrics #Pharmacokinetics #Neonatology #Antibiotics #MedTwitter ascpt.onlinelibrary.wiley.com/doi/10.1002/cp…

Latest in ASCPT Alexandria: 10 mg naloxone effectively reverses opioid-induced respiratory depression, especially with high-potency opioids like carfentanil. Early or double dosing enhances recovery rates! 💉💊📉 #Naloxone #Opioids #PublicHealth ascpt.onlinelibrary.wiley.com/doi/10.1002/ps…

A study in ASCPT Alexandria using AllofUsResearch data found that blood pressure med effectiveness & prescribing practices vary across racial & ethnic groups, leading to #HealthDisparities. allof-us.org/3McsPH1 [1/2]

New tutorial for researchers & clinicians by Pansari et al: Explore Physiologically-based Pharmacokinetic modeling to predict drug exposure in #breastfeeding infants and improve safety during lactation. bit.ly/3MUG4MP #PSPjournal #ASCPTjournals #ClinicalPharmacology

New insights into Parkinson's disease (PD) therapy! Anti-αSyn immunotherapy reduces αSyn aggregation in PD models, with microglial activation being a key target for treatment. bit.ly/3TFbkTO #PSPjournal #ASCPTjournals #ClinicalPharmacology #Parkinsonsdisease

New mechanism? No problem! Check out this article in our new video feature for CTS's Mechanism of Action mini-review. #ASCPTjournals #CTSjournal #JAKinhibitors Read the article here: bit.ly/47LQoQW