New review article in Med Res Rev, suggesting that the chemical space of RONS scavenging-related, oxidized metabolites of small-molecule antioxidants is a treasury of bioactive compounds. Exploring the "scavengome" offers a novel drug discovery strategy. onlinelibrary.wiley.com/doi/full/10.10…

Our new paper in Molecules MDPI describes potent antispasmodic agents from Morus nigra root bark. Moracin O is stronger than papaverin on rat ileal contractions and tracheal tone ex vivo, and is active at low nM concentrations on the latter. mdpi.com/1420-3049/24/1…

With Maurizio Botta, Professor and Medicinal Chemist at the University of Siena, the world lost a great scientist and human being, and all of us lost a good friend. In our memories he will continue to smile.

According to our recently published results, the furocoumarin content of fennel is below the safety level mdpi.com/1420-3049/24/1…

The NP Atlas website is finally up and running again. And there is a new version of the DB released! We thank you all for your patience. If there are any notable issues, please reach out to us here or email [email protected]

The Society for Medicinal Plant and Natural Product Research (GA) raises voice for protection of the Amazon, a most rich habitat of biodiversity and a treasury of medicinal plants. #AmazonFires #AmazonRainforest #HerbalMedicine #NaturalProduct

Wild passarine birds may be doping: our new article in Scientific Reports demonstrates the abundant presence of high levels of anabolic ecdysteroids in their blood, and this may possibly contribute to maintain their high rate of metabolism. disq.us/t/3jpxak9

Our new paper in IJMS MDPI reports a new natural product based lead against the Epstein-Barr virus, and shows that the SAR of protoflavonoids can be exploited to design non-cytotoxic derivatives with potent antiviral activity. MDPI mdpi.com/594340

Our phytochemical study on the weed Lindernia crustacea reveals several of its constituents active against the Epstein-Barr virus, and backs-up the antiviral traditional use of this plant. sciencedirect.com/science/articl…

It seems, that the popular antihyperlipidemic plant, chickweed does not treat hypercholesterolemia. Based on animal experiments at least it is safe. doi.org/10.1155/2020/5… life által

Phenolic Compounds from Morus nigra Regulate Viability and Apoptosis of Pancreatic β-Cells Possibly via SERCA Activity pubs.acs.org/doi/10.1021/ac…

Day 1/7 of #mylifeinpictures No people, no words. Nominate somebody every day. I was nominated by Maria Santos Today I nominate Patrícia Rijo

Our new paper in Antioxidants - fragment-based design of potent ATR inhibitor hybrid molecules as potent new antitumor leads. Plus: we show a new use for the Chou-Talalay method in evaluating hybrid compounds as a “virtual combination” of their fragments. mdpi.com/2076-3921/9/6/…

Check out our new review about the potential of epigenetic modifications to enrich/alter natural product profiles produced by fungi. link.springer.com/article/10.100…

ROS/RNS scavenging by methyl caffeate forms interesting metabolites, including a previously identified potent anti-tumor lead. Antioxidants + RONS may be a great guiding principle for diversity-oriented synthesis in drug discovery mdpi.com/886476 # via MDPI

What happens with the pollutants transformed through Cyril Raitt? In our new paper, we present discovery of highly unusual ecdysteroids, including some that might come from petroleum-polluted soil, in a worldwide consumed herbal food supplement. pubs.acs.org/doi/abs/10.102…

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New in RSC Advances 📣 Medicinal chemistry inspired by ginger: exploring the chemical space around 6-gingerol by Attila Hunyadi (Attila Hunyadi) et al. at University of Szeged 🤩 Read it here in full 🔓 ow.ly/VtXc50FOPIC #OpenAccess #Chemistry

Insectivorous bats seems to have discovered their own way for doping: their blood contains large amounts of various (anabolic) phytoecdysteroids that should have passed the food chain, from plants through insects into the bats. onlinelibrary.wiley.com/doi/10.1111/ma…

Check out our new paper reporting an exciting study on resveratrol: upon free radical scavenging in biomimetic/biorelevant systems, it is transformed into cardiovascular protective and antiinflammatory metabolites | Journal of Medicinal Chemistry pubs.acs.org/doi/full/10.10…