Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer biorxiv.org/cgi/content/sh… #bioRxiv

Leo James' lab reveals how TRIM21 facilitates ubiquitin transfer and differentiates its canonical E2 partner Ube2N from closely related enzymes @MRC_LMB @LeoKiss5 @AndreasBoland go.nature.com/2Nx7eM3

Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~Ub conformation biorxiv.org/cgi/content/sh… #bioRxiv

How disordered is your disordered protein?.........Very interesting project to work on with some great collaborations

Great work from all involved! The ubiquitin system just keeps on giving 😍

New addition to my top-of-the-line gravity columns 🤭

Well..........😀 Robust de novo design of protein binding proteins from target structural information alone biorxiv.org/content/10.110…

The end of the year is near, and we are launching a guessing competition as a #CountdownTo2022 with scientific images from the IMP. Play with us until 31st December! Winners will be mailed a gift. 🎁 The rules are simple 👇🏿 [1/2]

Very grateful to FWF for the opportunity, and really excited to continue my research IMP in @clausen_lab!

Please share with your networks! My lab is recruiting a research technician to help us in our quest to understand monstrously large antiviral E3s. my.corehr.com/pls/uogrecruit… Close date 10 August. Salary 22k-27k, funded until Jan ‘25.

Fantastic work from my colleagues julian ehrmann and @DanGrabarczyk (@clausen_lab) on E2/E3 hybrid BIRC6!