Protein Phosphatase 5-Recruiting Chimeras for Accelerating Tau Dephosphorylation | ACS Chemical Biology pubs.acs.org/doi/10.1021/ac…

We are live streaming #SCP2025 youtube.com/live/zJHoftV7M…

Cereblon (and its buddy, the cyclic imide) is Once Again in the spotlight! Excited to share the lab's latest pub, highlighting the effects of cyclic imide stereoisomers on CRBN activity! 🥳✨ Congrats to Yuka, Saki, and all the authors 🫶 pubs.rsc.org/en/content/art…

🚨 Introducing PSMtag from Parallel Squared Technology Institute (PTI)! I joined the project late, but the potential is huge — labeling proteomes with small molecules can transform how we study biology. We soon may even be able to rationally design tags with specific features! 😏

We performed global and systematic proteome analysis of Alzheimer's disease (AD). Our results suggest that decreased ubiquitin-proteasome system capacity and impaired clearance of proteins contribute substantially to proteopathic burden in AD. biorxiv.org/content/10.110…

This week, we published 4 preprints reporting: 1⃣ New new approaches for multiplexing & de-multiplexing proteomic data. 👉 Together, they scale throughput while preserving depth & accuracy. 2⃣ Protein degradation dysregulation in Alzheimer's 🧵 parallelsq.org/blog/proteomic…

In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

A highly compact chemically induced proximity system dependent on salicylic acid or aspiring enables control of biological processes and cellular therapeutics using an over-the counter drug with minimal side effects nature.com/articles/s4158…

Not guilty on everything except OUI. Karen Read is free.

Proud to be a part of this study and all the library prepping involved - kudos to the powerhouse Liz Lightbody! More to come from her!

High-throughput profiling of chemical-induced gene expression across 93,644 perturbations nature.com/articles/s4159…

What if treating disease meant stabilizing biology, not blocking it? We explore that idea in Science Magazine with LOCKTAC molecular glues, a new class of molecules that stabilize natural interactions to either boost or block biology. science.org/doi/10.1126/sc… #mycompnay

We mapped the zinc‑finger (ZF) “degrome.” High‑throughput ZF reporters + glutarimide analogs → new CRBN‑recruited degrons and design rules for degraders.

New paper in JACS: we show covalent chemistry isn’t just for proteins — it can make selective RNA-targeting small molecules. Found that 3-chloropivalamides crosslink RNA and used it to design a covalent binder of r(CUG) repeats in DM1. 🔗 doi.org/10.1021/jacs.5…

PTI is growing and we are looking for more scientists to join our team! Neurodegenerative Disease Senior Scientist: bit.ly/4n35ND7 Computational Biologist: bit.ly/4gplQsJ Research Chemist: bit.ly/46n0Q13

Excited to showcase published version of our covalent destabilizing MYC degrader in Angewandte Chemie that stereoselectively targets an IDR C203 in MYC! Congrats to Hannah Rosen and Kelvin Li & thanks to #TomMaimone, Novartis Science & The Mark Foundation for Cancer Research! onlinelibrary.wiley.com/doi/10.1002/an…

The bitter lesson of genomics: If you find yourself optimizing a targeted method, don't—betting against increased throughput is generally a bad idea.

🚨Breaking: Harvard University just announced massive cuts to dozens of its PhD programs, citing “financial pressure.” - Science PhD admissions reduced by more than 75% - Arts & Humanities reduced by about 60% - Social Sciences by 50–70% - History by 60% - Biology by 75% - The German

New from the Cravatt Lab! Tryptoline stereoprobes reveal hidden cysteine ligandability — while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones. Plus: GRPEL1 ligands disrupt its HSPA9 complex, rewiring mitochondrial biology. A masterpiece of chemoproteomics +

We show that running 100+ proteomic samples in a single DIA run is in reach! Check out how we are redesigning non-isobaric mass tags here at Parallel Squared Technology Institute (PTI)! biorxiv.org/content/10.110…