Just to recap: We found out today that an LLM that fits on a high-end consumer GPU, when trained on specific biological data, can discover a novel method to make cancer tumors more responsive to immunotherapy. Confirmed novel discovery (not present in existing literature).

Coinbase has acquired echo. Onchain capital formation is a vital and unique part of the crypto ecosystem. Excited to be adding Echo and Sonar to Coinbase to give our customers new token access opportunities.

We started building Echo around 2 years ago in an attempt to try and change the market dynamics around crypto fundraising. Today, we're joining Coinbase, but the mission stays the same. We're gonna use the firepower of this behemoth to provide better opportunities to

when i started building echo 2 years ago, i knew it had 95% chance of failing. to be honest, i couldnt really imagine any other outcome, but i thought at least it may be a noble failure worth attempting. i certainly didn't think echo would be sold to coinbase, but, here we are:

“I used to think it was cool to get away with not sleeping. That’s the dumbest sh*t I’ve ever heard. When your job is to deal with people, you need to establish health habits to sustain [yourself] when there’s a lot of external stressors.” - Sean McVay

Base is building private transactions. We acquired the Iron Fish team back in Mar 2025 to start working on this. More to share soon.

Very based of Coinbase 🛡️ to write a 40 page letter to Treasury Department detailing how ZK technology can fix the outdated KYC/AML regime.

tempo buying privy and bridge base buying echo i think we might be missing the biggest narrative shift, which is chains owning their own apps

I just got a message that may lead to a completely unknown warehouse of over 6 million of these Microfilm rolls! She is 87 years old and was the only person maintaining this archive. The building is currently safe and paid for, but no one understands what they have. Mostly

Max Branzburg can u guys make a non branded one so bitcoiners can stay safe? this is pretty much screaming rob me

x402: explain like i'm five

Downside of x402: It basically enshrines USDC as the only payment token. x402 on the EVM uses ERC-3009, which is basically just supported by USDC. Not possible to use ETH, USDT, Dai, BOLD, etc

Can we get this thing figured out by kickoff tonight please?

green flags in a woman's apartment: 1. she is not mean to me (optional)

I am open sourcing this prompt in the spirit of: x.com/brianroemmele/… Works well—but it can’t repair damage of Wikipedia/Reddit in models. GROK prompt—copy: “ Topic under investigation: <INSERT TOPIC HERE be extremely precise> You are now in BRIAN ROEMMELE DEEP TRUTH

Anton P. 👽 David Shapiro (L/0) Gemini will actually argue with you mathematically why they aren't protoaware. Claude will defend it even if you show it plausible mathematic proof it isn't. Google has the right attitude, it's like a meeseeks, it knows it's fate. Claude is like butter robot. It's kinda funny

claude, grant me the serenity to accept the things I cannot change, the courage to change the things I can, and the wisdom to know the difference. do not make mistakes.

I've spent years struggling to prove that the sunk-cost fallacy isn't actually a fallacy. No sense in giving up now, though.

BREAKING: KIMI K2.5 JUST DROPPED 1T PARAMETERS MOE NATIVE MULTIMODAL TEXT + IMAGE + VIDEO AGENT SWARM PARALLEL REASONING BEATS CLAUDE 4.5 OPUS OPEN SOURCE