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Correlation Vs. Causation

When we express fluorescent sensors via AAV in mice, we usually wait >2 weeks for expression. I guess we're waiting for reporter concentration to build up. Does anybody know how long it takes from injection until AAVs initially become "active"?

this is inspiring

fascinating work! congratulations Kaibin! 🥳

I love our spinning disk confocal microscope

Gradcafe and google sheets are two main anxiety source in graduate application season

Inverse Activity Marker is now published in Neuron Incredible team and many collaborators. cell.com/neuron/fulltex… Major updates from preprint. Don't hesitate to reach out. We are eager to know how it works in the field and to help. Lab protocol on our website.

We are thrilled to share a new study from the lab on the neural mechanism of helping behavior. Humans and animals exhibit helping behavior toward others in need. In this study, we report an intriguing form of helping behavior that an individual exhibits toward others experiencing

Nature research paper: Synaptic wiring motifs in posterior parietal cortex support decision-making go.nature.com/42UCYj9

Excited to share our paper on mouse DRG genetic toolkit that reveals morphological and physiological diversity of somatosensory neuron subtypes. Thanks to all the co-authors! cell.com/cell/fulltext/…

Is it already feasible to image subcellular structures (or even single molecules) in vivo in the adult mouse brain (eg. ER, mitochondria...)?

Convincing evidence of artifactual calcium micro-waves during calcium imaging of populations of neurons in the hippocampus. elifesciences.org/reviewed-prepr…

Congrats to my colleagues back in PKU!

6 main figs and 5 supplementary figs .

#PR Our ms on postsynaptic competition btw CaN/PP1 & PKA regulates mammalian sleep/wake cycles published in Nature. Congrats, Yimeng, Siyu, Daisuke and Koji! Wake/sleep roles of PKA & CaN first found in fly by Amita Sehgal in 2006 & Kume Kazuhiko 粂　和彦 in 2011 nature.com/articles/s4158…

Glad to share our newest work as a bioRxiv preprint biorxiv.org/content/10.110…. The cerebellum is more than motion and reward processing. We found that feedforward, subjective decision information can reach the cerebellum via climbing fibers to direct animal behavior.

Very excited to share the first paper from my lab. We engineered a new PTEN sensor that permits dynamic imaging in living cells. We showed that this allows to visualize PTEN activity with subcellular resolution in the intact brain. Now published in Nature Methods

This is the most important open source structural biology model release since AF3. Huge props to the Baker lab for open sourcing end-to-end antibody design github.com/RosettaCommons…