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Thrilled to share that I'll be starting a tenure-track assistant professor position at the Department of Genetics, Washington University in St. Louis, in January 2025! WashU Medicine Genetics I am recruiting lab members at all levels. For more details, visit our lab website or check flyer

Qiqi Cao and I wrote a N&V for this fantastic paper on #oocyte TFs and **STRANGE** oocyte #enhancers Nature Cell Biology Congrats to 1st authors: Bofeng Liu, Yuanlin He, Xiaotong Wu, Zili Lin, Jing Ma & labs of Jing Li & Wei Xie tinyurl.com/3f7symae tinyurl.com/jmrkmzjz

Delighted to share our study out today in Science Advances, led by Atma Ivancevic Atma Ivancevic on endogenous retroviruses functioning as MAPK-regulated enhancers in colorectal cancer!

Excited to share the publication of 'Molecular Mechanisms Determining Mammalian Oocyte Quality', edited by me, including outstanding chapters from Karen Schindler Dr. Karen Schindler, Jennifer Wood Jennifer Wood, Joe Qiao, So-Youn Kim So-Youn Kim and Mike Lampson, and their teams.

Our paper about TE's regulatory functions using ENCODE data has been published! nature.com/articles/s4146… Ting Wang Cedric🧬➰🧬Feschotte We confirmed TEs contributed 25% of regulatory elements in the human genome. We also investigated how different TEs contributed differently. /1

Job Alert!! The UPenn Center for Women's Health and Reproductive Medicine is hiring tenure track Assistant Professors, with a special interest in endometrial biology, gyn cancers, pregnancy and reproductive processes. Apply soon: apply.interfolio.com/153614

Our new paper is out Nature Cell Biology🥳It shows how major epigenetic OFF mark, H3K27me3, is newly established at the beginning of life. This work was mainly carried out by a talented PhD student, Masahiro Matsuwaka👏 nature.com/articles/s4155… rdcu.be/dYJf Short summary↓↓

Happy to share our latest publication in Nature Communications led by active graduate students, Fei Sun and Nourhan Ali! We found that increased DNA damage in full-grown oocytes correlates with diminished autophagy activation. nature.com/articles/s4146…

We are so excited to share our work on the establishment of bovine extraembryonic endoderm cells and another bovine blastoid model for studying embryogenesis. Congratulations to all co-authors. biorxiv.org/content/10.110…

Our review on the interplay between Pioneer Transcription Factors and epigenetic modifiers in cell reprogramming is out ! Check it out here: sciencedirect.com/science/articl… Cincinnati Children's Development, Stem Cells, & Regen Med PhD Program Samuel Sampson

Our newest preprint for the pilot study of cell-free DNA methylation as the biomarker for multiple sclerosis to simultaneously classify MS subtypes, evaluate disability severity, and predict long-term progression. Collaboration work with Li Wang and Dr. Zongqi Xia!

Multiplex-edited mice recapitulate woolly mammoth hair phenotypes biorxiv.org/content/10.110… #biorxiv_genetic

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 biorxiv.org/content/10.110…

Our first extraordinary biologist this week is Meng Zhu, former preLighter and Development presents… feature, who has been instrumental in the working group of Chinese early-career researchers consulting our WeChat channel. #100biologists

Excited to share our latest study showing that restoring the balance between NTRK2 isoforms offers a promising therapeutic approach to promote pulmonary vascular regeneration! biorxiv.org/content/10.110…

Thrilled to share our paper Cell Reports where we established bovine XENs and a new blastiod protocol- Another milestone in bovine stem cells! Establishment of bovine extraembryonic endoderm stem cells enables efficient blastoid formation: Cell Reports cell.com/cell-reports/f…

A Universal 6iL/E4 Culture System for Deriving and Maintaining Embryonic Stem Cells Across Mammalian Species biorxiv.org/content/10.110…

I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in Science Magazine ! (link at end of 🧵)

Our new paper is finally out, uncovering the distribution of H2A variants in mouse oocytes and the epistasis between H2A.Z and H3K4me3 across intergenic regions. nature.com/articles/s4159… Short summary in thread↓↓ (1/9)

Excited to share our recent work on organoid vascularization, now out in Cell! Grateful to all our amazing collaborators who made this possible! CuSTOM UCLA Broad Stem Cell