Cold-induced thermogenesis requires neutral-lipase-mediated intracellular lipolysis in brown adipocytes dlvr.it/THpFjS

Time to show up! #colorado #standupforscience2025

Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how ageing affects mitochondrial function in mice. 🔗 elifesciences.org/articles/10519…

Does the lack of correlation between PGC1a RNA and protein give you a headache? Us too. Phillip Dumesic has uncovered a key factor controlling PGC1a mRNA translation authors.elsevier.com/a/1kdIZ5WXUlaX…

Divergent Multiomic Acute Exercise Responses Reveal the Impact of Sex as a Biological Variable journals.physiology.org/doi/abs/10.115…

Pleased to share our new review with Greg_Steinberg outlining the role of the gut-adipose tissue-liver axis in MASLD. Integrative Metabolism in MASLD and MASH: Pathophysiology and Emerging... sciencedirect.com/science/articl…

Our review: "Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?" in ANNUAL REVIEW OF PHYSIOLOGY with Martin Picard & Matt Lee is now Online: bit.ly/3WGl2H5

Pleased to share our newest paper describing a new mechanism for fatty acid transfer between lipid droplets and mitochondria, which is important for regulating fatty acid oxidation. A wonderful team effort and work that I’m extremely proud of. nature.com/articles/s4146…

Extracellular vesicles for the delivery of gene therapy bit.ly/4kr6sxj

Pleased to share our recent work showing the protein HEXA improves #muscle insulin sensitivity in mice with type 2 #diabetes. Superbly led by Magda Montgomery UniMelb MDHS rdcu.be/efJo0

Today in Nature Communications, we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats Jakub Bunk! Full paper: rdcu.be/egoV7 Rosalind & Morris Goodman Cancer Institute

Mitochondrial fission regulates midgut muscle assembly and tick feeding capacity dlvr.it/TJydz3

Last night I was honored to receive the 2025 #BreakthroughPrize in the Life Sciences, reflecting the efforts of many students, collaborators, doctors, and patients in labs around the world. I hope this 4-minute excerpt can inspire when science needs public support more than ever.

Adipose tissue generates heat even in the absence of UCP1. How does it work? Our new work identifies a molecular “resistor” of Ca2+ cycling that makes heat and controls energy metabolism through a UCP1-independent mechanism. sciencedirect.com/science/articl…

Highly dynamic and sensitive NEMOer calcium indicators for imaging ER calcium signals in excitable cells nature.com/articles/s4146…

Nature research paper: Cold memories control whole-body thermoregulatory responses go.nature.com/4lK37dx

We are hiring postdocs. If you are passionate about using iPSC, CRISPR screens, organoids, and multiomics to understand cardiovascular disease and advance precision medicine.

Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males cell.com/cell-reports-m…

5 websites to analyze GEO RNAseq data without a single line of code 👇

Parkin overexpression attenuates muscle atrophy and improves mitochondrial bioenergetics but fails to improve key histological features in a mouse model of Duchenne Muscular Dystrophy | bioRxiv biorxiv.org/content/10.110…