Happy to share our methods chapter on quantifying force-mediated antigen extraction in the B cell immune synapse 🧬 🔬 Dr Hannah McArthur Katelyn Spillane : sciencedirect.com/science/articl…

Check out our new Confinement Mechanobiology Lab at MBI review in APL Bioengineering! Mechanical memory is an important concept in #mechanobiology and #confinement! We hope to convince the field to consider timescales⏱️when engineering systems that provide mechanical stimuli🔨 pubs.aip.org/aip/apb/articl…

Thrilled to share a new approach to viral diagnostics using mechanical transduction. Here we use DNA motors to "feel" viruses -with sensitivity down to the single virus level. Selma salaitalab Emory Chemistry pubs.acs.org/doi/10.1021/ac…

" Integrins are molecular machines w/ parts that undergo large, ∼100 Å movements; however, we believed that we could not understand this machine and truly appreciate its soul—its animating principle—until we saw it move. "- Li et al. -What a tour de force cell.com/cell/fulltext/…

We are excited to share our review with salaitalab on the mechanical regulation of TCR and BCR activation. The idea for this review came about over lunch with Khalid Salaita at the 2023 ImmunoBiophysics meeting in Les Houches, and I’m very happy to see it come to fruition.

We visualized pauses and steps in the motion of DNA-AuNP artificial motor, and largely improved its speed and processivity by using prediction from geometry-based kinetic simulation which reproduces experiment quantitatively! Takanori's great achievement! biorxiv.org/content/10.110…

Thrilled to announce our latest paper in Nature Communications revealing a novel mechanism of alpha-synuclein spread between neurons. Despite challenges, our team's dedication has been unwavering. Excited for what lies ahead with such a talented group! Parkinson's Foundation Research Cure Parkinson's

🚨Our paper on the confined migration of autonomous cell clusters is now out in Nature Physics 👏 Wonderful collaboration with Edouard Hannezo David Brückner Xavier Trepat and incredible work by Eleonore Vercruysse with Luciano Marine and Kalukula Yohalie Université de Mons nature.com/articles/s4156…

#methods_highlight Lots happening in molecular tension probes! In addition to the work from the Ha lab we highlighted last month, Zheng Liu has a nice paper on DNA-based ForceChrono probes for deciphering single-molecule force dynamics in living cells. cell.com/cell/abstract/…

🤩🤩 Feeling a little starstruck hanging out with Sunney Xie!!

Here we report the DNA Origami Tension Sensor (DOTS) & measure TCR-pMHC forces in cell-cell junctions! Forces measured using microscopy or flow cytometry! Emory Chemistry⁩ ⁦Yuesong Hu⁩ ⁦salaitalab⁩ ⁦Emory University⁩ nature.com/articles/s4156…

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

Thrilled to share our back-to-back two Nature nature papers on the unexpected role of type 2 immunity against cancer. We found that interleukin 4 (Fc–IL-4), a type 2 cytokine, reinvigorates exhausted T cells to potentiate anticancer immunotherapy w/ Yugang GUO Rong Fan(1/11)

We make it to the cover Nature Biotechnology! the IL-10-CAR-T cells eradicate solid tumors! nature.com/articles/s4158… The IL-10-CD19-CAR-T cells have shown promising clinical results in several investigator initiated trials too. Stay tuned! #SOHC ESMO - Eur. Oncology ASH

Our extensive review on "Computational Super-Resolution: An Odyssey in Harnessing Priors to Enhance Optical Microscopy Resolution" is online at pubs.acs.org/doi/10.1021/ac… Wenfeng put a lot of heart and soul into it. So I believe that it is worth reading😀

We just published a review on recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd.20… #mechanobiology

Just shared a review on mechanosensing protein linkages — their roles in force transmission and potential as therapeutic targets. 🔗 pubs.aip.org/aip/apb/articl… #Mechanobiology #ProteinEngineering #DrugDiscovery Mechanobiology Institute

It’s finally out!!🥳 Check out our paper in Nature Materials on a new hybrid scaffold where we discover ECM-specific cues that regulate cardiac aging 🔗 nature.com/articles/s4156… This is the lab’s 1st research paper, led by my 1st Nus Bioeng PhD student 𝐀𝐯𝐞𝐫𝐲 𝐒𝐮𝐧🤩 Tweetorial👇

Check it out at PNAS today. Thank you Alexandre for the collaboration!! PK Mem probes offer long time-lapse imaging of cell membrane dynamics. Made possible by Jing Ling, Yitong Liu, and all the collaborators! Available Spirochrome