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This is so cool! nature.com/articles/s4156…

A new type of microbe discovered in the human gut! Called obelisks, they can create their own proteins that are entirely new to science. The team named their proteins “oblins.” Scientists scratching their heads about it biorxiv.org/content/10.110…

The generative machine learning tool RENAISSANCE generates kinetic models that accurately characterize cellular metabolic states nature.com/articles/s4192… #NBThighlight

I can’t explain it but this image makes me want to go to a conference where people exchange tiny posters with QR codes on the back to the full poster

Nobel Prize in Physiology or Medicine: Biology Nobel Prize in Chemistry: Biology Nobel Prize in Physics: Sounds like Biology #NobelPrize

Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman go.nature.com/4hp4UCP

In London and curious about entrepreneurship? We’re coming to Imperial and the Crick! Alex Teng and I are hosting fireside chats next week. We’ll share our insights from helping 100s of scientists and engineers translate breakthrough science into deep tech startups. RSVP 👇

In new work led by Aditi Merchant with Samuel King, we prompt engineer Evo to perform function-guided protein design with high experimental success rates, including designs that go beyond natural sequences. We also release SynGenome, the first AI-generated genomics database. 🧵 1/N

My prior post below re China x US biotech has caught the attention of a few of you Why am I well positioned to comment on the situation? A short backstory: In 2021 I co-founded precision oncology biotech, @melioratx, based in Boston and SF. We work on covalent allosteric

✨ 𝗛𝗲𝗹𝗹𝗼 𝟮𝟬𝟮𝟱 – I’m heading to 𝗦𝗮𝗻 𝗙𝗿𝗮𝗻𝗰𝗶𝘀𝗰𝗼 🇺🇸 from Jan 12-18 for the J.P. Morgan Healthcare Week #JPM2025 🧬💊🔬. If you’re around or know someone who will be, I’d love to meet up ☕️🧋🏃🏻‍♀️ - founder, investor, or scientist. #JPM25 #biotech HCVC

Defense 🤝 Biotech The DoD Office of Strategic Capital (OSC) started the year with a bang announcing a new loan program for supply chains in critical industries with a big spotlight on industrial biotech. 4 of 15 DoD Industry Segments of Particular Interest (biochemicals,

Standing room only Q&A session yesterday on how to build a deep tech company, with Isabel Zhang 🧬🦾 presenting the HCVC Synthesis Fellowship, and Francesco Marchioni of Stanford Founders. Thanks everyone for the great questions!

1) DeepSeek r1 is real with important nuances. Most important is the fact that r1 is so much cheaper and more efficient to inference than o1, not from the $6m training figure. r1 costs 93% less to *use* than o1 per each API, can be run locally on a high end work station and

📢Excited to introduce NanoCas -our new mini CRISPR system that can reach tissues previously out of reach! By shrinking CRISPR to 1/3 its normal size, we can now edit genes in muscle, heart & brain that were difficult to access before. Summary & link to paper:

EUROPE IS COMING BACK 🇪🇺 This September, Europe’s finest and most ambitious builders unite at a historic location in Berlin. Join us for a fresh dawn of European tech. All-in on Europe. europeanbuilders.com

I’m having way too much fun with these. Any ideas?

Studio Ghibli style — physics version ✍️ 🧵

Biologists have built one of the most detailed pictures of pregnancy's true toll on the body. Read the full story: go.nature.com/4hUpNES

Introducing Alljoined (Alljoined), my new thing! By applying deep learning to large-scale EEG datasets, we aim to decode the entirety of the conscious experience non-invasively. Proud to be backed by Khosla Ventures, with participation from Conviction, Compound, Artis, Xtal,

The gene editing tool STITCHR contains an R2 retrotransposon fused to a CRISPR–Cas9 nickase to install diverse edits, including multi-kilobase insertions, in vitro. nature.com/articles/s4158… #NBTHighlight