Faculty Positions in AI for Life Sciences at Westlake University nature.com/naturecareers/…

A brief musical note: I’m very excited to share that my brilliant wife, a pianist and composer, has just released her debut album featuring works by Iranian women composers, including one of her own. Here is the link in case you’d like to take a listen: navonarecords.com/catalog/nv6747/

This work driven by Ji Tang is now officially published! x.com/AJHGNews/statu…

The method for revealing ancestry-specific structures in admixed populations is published! Many thanks to my postdoc advisor Charleston Chiang and the members in the lab! I'm making this method as easy to use as possible, feel free to try it out at github.com/jitang-github/…

Very happy to share our new paper now on medRxiv: “Genetic risk effects act in sets”, a great effort led my PhD student Jolien Rietkerk, and performed together with collaborators Andy Dahl, Andrew Schork, Jonathan Flint etc. Thread 1/n

Excited to share that scPRS is now out Nature Biotechnology! We developed a new single-cell-resolved #PRS using deep learning. nature.com/articles/s4158…

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational and statistical methods in human genetics or genomics. Please share!

Excited to share a review paper we have written on statistical fine-mapping!

excited to share our new preprint looking at mosaic chromosomal alterations in blood whole genome sequencing data! i learned tons working on this project, and i hope our findings are of interest to those thinking about CH, somatic mosaicism, and genetics. medrxiv.org/content/10.110…

Genetic "optimization" of embryos appears to be becoming mainstream. The narrative currently is largely controlled by startups that range across the spectrum from hardcore snake-oil to well-intentioned & occasionally strong domain expertise. But these are not neutral parties. 1/

A few thoughts on Herasight, the new embryo selection company. First, the post below and the white paper imply that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

Excited to share our paper, Health risks and genetic architecture of objectively measured multidimensional sleep health, led by Shengkui Zhang, Manrui Zhang, and Yuxin Yuan, is now online in Nature Communications🎉 Many thanks to co-authors, Xiaoyu Li and Zilin Li, and to all

One of the more pathetic features of the online racist ecosystem is the immediate whining whenever their ideological project is pointed out. If you're collaborating with white identity / remigration journals and politicians, YOU are engaged in politics. Just own it!

The proportion of epistatic heritability that is estimated as additive by quantitative genetic models. Epistasis deviates more from additivity for lower frequency causal alleles, but on average >80% of biological GxG will just look like statistical G.

One thing that took me a long time to grasp is the difference between narrow-sense heritability (h2) and SNP heritability (h2g), and why performing the same estimation method on related samples gets you the former, but on unrelated samples, it gets you the latter. Here’s why: 🧵

New preprint on a surprising question - with a pangenome reference, *what is a genetic variant?* biorxiv.org/content/10.110… With Pouria Salehi Nowbandani, Shenghan Zhang, Haoyang Hu, and Heng Li Heng Li

Monotone convex transformations of an additive phenotype induce sign-consistent GxE--new preprint from Michal Sadowski, Noah Zaitlen and Richard Border