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Are you curious about using organic dyes in your microscopy experiments but not sure where to start? This Perspective from @rhodamine110 and Jon Grimm @dyerfulchymist.bsky.social introduces readers to the world of dyes and their pros and cons for biological applications. nature.com/articles/s4159…

Very excited to share this PNASNews paper on the mechanism of tissue-specific #mRNA delivery using SORT #LNPs . Here we provide evidence for an endogenous targeting mechanism. Congrats to Sean and Qiang! @UTSWNews @utswBMEprogram pnas.org/content/118/52…

Seven technologies set to shake up science in 2022 go.nature.com/3FZBC9P

Have fun at my first #TorontoMarathon !!

New content online: A pyroptosis nanotuner for cancer therapy dlvr.it/SQvz1x

3D view of clathrin & caveolae at the cell membrane #ET

Gangsters reunion at the NanoMedicines Innovation Network Scientific Meeting! 🎉Congrats Yulin Mo and Michael Valic on your poster awards and Tiffany Ho on your NMIN ATC Silver Certification! 🔥

Fresh new paper from the Zheng lab on ACS Nano ! "Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles" pubs.acs.org/doi/10.1021/ac… Congrats Yulin Mo and co-authors!

Excited to see this paper is finally out! We have shown that incorporating porphyrin-lipids into the clinically approved Onpattro formulation enables light-activated siRNA endosomal release (LASER). Big thanks to everyone on the paper!

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

It’s amazing experience chatting with all the great scientists in the field! I really enjoyed and learned a lot in the LRD conference. Big thanks to Dr. Yvonne Perrie and the organizing committee!

Just out in Nature Reviews Drug Discovery "60-year evolution of #LNP for nucleic acid delivery" by legends Pieter Cullis University of British Columbia and Phil Felgner UC Irvine nature.com/articles/s4157…

Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles | Journal of the American Chemical Society U of T Research University of Toronto Princess Margaret Cancer Centre pubs.acs.org/doi/10.1021/ja…