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In a new Science paper, researchers describe how they stereoselectively snipped a C–H bond and added aryl groups to the position three or four atoms away from the carbonyl carbon of cyclic carboxylic acids: cen.acs.org/synthesis/c-h-…

So humbled to be added to this incredible list and grateful to pharma colleagues for the recognition of CH reactions enabled by our bifunctional ligands. Advertisement for the symposium: Will share many stories of CH reactions in Drug discovery.

Very special to receive this medallion made of Pd. No chemistry lecture needed, instead I gave a brief dinner speech to this fun metal industry audience: “Pd, my best encounter in life” The audience bursted into laughters badly.

What did I praise Palladium during the speech? Handsome color; versatile with partners; flexible going up or down; non temperamental and kind; nontoxic and forgiving; forever available due to electric cars. What else can you ask from a friend ?

C-H activation highway for making chiral carbocycles that are not feasible via Diels-Alder due to mismatch of electronic effects. Dehydrogenation was one of our first proposed reactions in 2003, and is still one of our favorite pursuits.

forgot to add a link to the publication: Synthesis of chiral carbocycles via enantioselective β,γ-dehydrogenation | Nature Synthesis

Yamada-Koga asymmetric lithiation is part of the inspiration for our first project on asymmetric CH palladation in 2002. This recognition is so special to my coworkers: CH activation is finally a significant member of the asymmetric catalysis family, huge potential to yet improve

CH Lactonization is a way for oxidation. we have done beta lactone, now gamma lactones. Controlling site-selectivity between CH3 and CH2 by catalyst is really challenging: pubs.acs.org/articlesonrequ…

Amazing collaboration with Stoltz group Caltech and Davies group Emory University! Our part was to achieve tetra-CH hydroxylation via weak coordination at very late stage of complex total synthesis: science.org/doi/10.1126/sc…

Wonderful host. Great talks from jesse lab, Ramesh Giri (रमेश गिरी) and collaborators from BMS and Vividion. Chemistry really matters in drug discovery.

Today marks a monumental milestone: 100 years of pioneering science at Scripps Research. 🎉 On December 11, 1924, philanthropist and journalist Ellen Browning Scripps laid the foundation for what would become a globally renowned institute. Learn more at 100.scripps.edu.

Design of chiral bifunctional ligands Continues to expand the scope of enantio-CH activation reactions, even when FG and CH are out of plane. Next will be ketone to conquer…

EJ: the man, the myth, the legend

A magic spoon of table salts for aliphatic acids in 2007 guided us along the path of CH activation based on weak coordination, leading to discoveries of 10 distinct classes of bifunctional ligands so far, but ketones are too slippery until now: Nature: 10.1038/s41586-024-08281-4

First in class pain killer FDA approved: endpts.com/vertexs-non-op…. Great fun memories working with Vertex on CH editing of this THF, THP scaffolds. 80 M patients annually could benefit

New chemical space in drug discovery means positioning H-A, H-D, pi-interactions, etc within various distal and geometric relationships at angstrom precision. CH activation at different sites have now arrived in large quantities to do just that: cnbc.com/2025/01/30/fda…

EnantioCH by our MPAA ligand fills a gap in chiral technology; creating new chemical space for both drug discovery and chiral ligands: pubs.acs.org/articlesonrequ…

A high bar for CH reactions to be relevant for sustainable polymer synthesis. Incredible efforts from a Germany Tech Institute to improve and pressure test one of our C-H reaction towards industrialization, even solvent needs to be omitted: just soap in and gold out!

Enantioselective CH activation is still on gas pedal. for broad applications, we must develop new catalysts for reacting CH with nucleophiles: pubs.acs.org/doi/10.1021/ja…. What is your wish list? NaF? NaCl? H2O? NH3?

Weak coordination is very powerful with the help from bifunctional ligands; making secondary alkyl-fluoride building blocks from diverse simple substrates is highly valuable in drug discovery: pubs.acs.org/articlesonrequ…