Dual-payload ADCの最新動向をまとめた総説 mAb誌より。OA タイムリーな話題ですね tandfonline.com/doi/full/10.10… 本総説では、均一なdual payload ADCの最新技術と、それに伴う製造・解析・薬理学的課題を包括的に整理しています 以下メモ ・二重ペイロードADCの目的

Excited to share our new strategy to access carbenes - of all electronic types! Congrats to Khue, Xueling, Bethany, Mohamed, Jake, Young, & Ilias on their beautiful work in Science Magazine! science.org/doi/10.1126/sc…

🚀Skeletal editing of ketones using [1.1.1]propellane to access functionalized MCB-ketones and spirocyclic scaffolds is out ChemRxiv. A fantastic collaboration with Mykhailiuk Chem 🇺🇦. Thank you, Anusandhan National Research Foundation and IISc Bangalore, for the financial support. chemrxiv.org/engage/chemrxi…

糖化学とBioconjugationにおける、メタルフリーClick chemistryの進化 pubs.acs.org/doi/full/10.10… Bioconjugate Chemistryより、OAです

Our group’s mission: exploring the synergy between organic chemistry & technology. In our new J. Am. Chem. Soc. Perspective, we highlight 6 technologies reshaping synthetic organic chemistry: ⚙️ Flow 💡 Photo ⚡ Electro 🌱 Bio 🌀 Mechano 🤖 Automation 👉 doi.org/10.1021/jacs.5…

Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis - Sephton - Angewandte Chemie International Edition - Wiley Online Library 簡便なシクロプロパン化反応をたくさん知っておきたいので要チェックです (ジエチル亜鉛使いたくない。笑) onlinelibrary.wiley.com/doi/10.1002/an…

Isolation and Characterization of an Organobismuth Dihydride | Journal of the American Chemical Society Cornellab pubs.acs.org/doi/10.1021/ja…

Here is our latest study in Chemical Science! This covers the mechanisms by which 1,2,3-trienes, anti-Bredt olefins, & other unusual compounds arise from Kobayashi precursors. Congrats to @zachwalterschem & Dom! doi.org/10.1039/D5SC03… @ucla UCLA Chem & Biochem @Houk1000

The Opportunity to go Beyond “Chemo on a Stick” ADCs adcreview.com/the-opportunit… ADC Reviewより、OAです 現在のADCには限界があり、次の進化が必要だと提唱しています。 これまでのADCの課題: 従来のADCは、強力な抗がん剤を抗体に結合させたもの（「ただの抗がん剤をくっつけただけ」）でした。

🚨Simple neutral acridines work as N-centered radical d-HAT photocats!💡🔄engaging C-H bonds of even light alkanes! vs scarce examples of (ionic) NCR PCs, we report a general platform incl. 2-/3-component rxns, heterofuncs, & dual catalysis w/ Ni & Cu🤝 👇 tinyurl.com/mr342ush

Interested in strain-release and bioisostere synthesis? Check out our new Sm(II)-catalyzed ♻ process in Angewandte Chemie! Sm(II)-catalyzed strain-release coupling of housane ketones with alkenes give decorated norbornanes not easily made by trad methods. Congrats to the team! 🔗👇

Online now: Stereoselective C(sp3)-Si/Ge bond formation via nickel-catalyzed decarboxylative couplings dlvr.it/TMcYYz

A #ChemEd #Chemistry intro to the frontier molecular orbital view of electrophilic addition to alkenes. It is a companion to the last one (x.com/nz_molecules/s…). It is an oversimplification but useful at #UG level. It shows the limitations of curly arrow mechanisms. Enjoy.

Copper-catalysed enantioconvergent O-alkylation of alcohols with racemic α-tertiary haloamides to access enantioenriched hindered dialkyl ethers bit.ly/4p3Xh8D

Diazene chemistry? ✅ Photocatalyzed EnT? ✅ Radical sorting? ✅ Your new favorite method for C–C bond formation? ✅ Check out our lab's newest work now published in Chem! Congrats to our awesome team led by Deepta on this beautiful chemistry! tinyurl.com/2rwzwpej

pubs.rsc.org/en/content/art…

Extremely happy to publish this invited review article on harnessing NCIs as part of the Women in Catalysis series of ChemCatChem Chemistry Europe Congratulations to Sanat for leading the paper, congratulations to Bijoy IIT Kharagpur🇮🇳 on his first publication. shorturl.at/NQcPG

修士課程の途中ではじめた研究がやっと終わった😭 あとは……学部と直近の研究をさっさと終えたいな 1番嬉しいのは学部から有機化学がずっと好きな思いだけは途絶えずに今日まで過ごせてよかった……

Online now: Rewriting lysine reactivity: Lysine-targeted bioconjugation via biomimetic polarity reversal for diversified biomolecule modification dlvr.it/TNHl1v

こちら、追記すると言いつつ3か月たちました。失礼いたしました。 この論文は、バイオコンジュゲーションの分野における効率的な「ダブルクリック戦略」の開発に関するものですね 以下の2つの直交するクリック反応を組み合わせています ・銅触媒によるアジド-アルキン環化付加反応（CuAAC）