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It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

I’m thrilled to share this story from Joshua Mendell and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation. science.org/doi/10.1126/sc…

Our #CellLineOfTheWeek is Nucleoporin Nup153! 🧫 Our human iPS cell lines & plasmids – fluorescently-tagged to illuminate structures – are available for just the cost of shipping to support scientific discovery. 📦 Distributed by Coriell Institute & Addgene

Beautiful work! Congrats!

Looking forward to this meeting that brings together scientists from academia and industry! conferences.nature.com/r4VPMo?sms=2

Congrats Valérie!

Bravo to Wendell Lim, PhD, and team for making the cover of Science Magazine! The team armed immune cells with “molecular GPS” to find and treat brain cancer, MS and type I diabetes. Clinical trials could begin as soon as 2025. Cell Design Institute @UCSF ARPA-H National Cancer Institute tiny.ucsf.edu/BeJ9N2

Start the new year with a new publication! Led by the talented postdoc Yoseop Yoon ! RBBP6 anchors pre-mRNA 3′ end processing to nuclear speckles for efficient gene expression: Molecular Cell cell.com/molecular-cell…

A new study from our long-term collaboration with Roger Sciammas' group UC Davis studying the regulation of the alternative polyadenylation switch in IgM during B cell development! Distinct plasmablast developmental intermediates produce graded expres... sciencedirect.com/science/articl…

A human gene makes mice squeak differently — did it contribute to language? Lovely article by Ewen Callaway going into the contribution of human-specific NOVA1 variant to vocal communication nature.com/articles/d4158…

Axonal RNA localization is essential for long-term memory: nature.com/articles/s4146…

RNA lovers, mark your calendar for this exciting meeting (August 19-23)! Abstract due: May 30 meetings.cshl.edu/meetings.aspx?…

Excited to share our new preprint on co-transcriptional splicing! U1 snRNP is recruited to RNA polymerase II through multiple interaction sites, with elongation factor SPT6 binding directly to the U1 snRNP protein. biorxiv.org/content/10.110… #cryoEM #transcription #splicing

Postdoc positions are available for deciphering the nuclear RNA degradation code! Email me if interested! A nuclear RNA degradation code is recognized by PAXT for eukaryotic transcriptome surveillance: Molecular Cell cell.com/molecular-cell…

😂😅😓😥

Iron deficiency during early embryonic development can induce sex reversal, making an XY embryo grow ovaries instead of testes. Fascinating! The SRY gene (Sex-determining Region Y) located on the Y chromosome encodes a transcription factor that plays a key role in sex