A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease by Yongjin Yoo, Marius Wernig & colleagues hubs.li/Q037Z2tQ0 Open stem cell research from Cell Stem Cell

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease | Nature nature.com/articles/s4158…

🧠Have you ever cried when your #iPSC transgene vanished after differentiation? Yeah, we’ve cried too, and built a solution. Our PiggyBac vector keeps expression stable even after differentiation! Check out our #preprint👇 🔗 biorxiv.org/content/10.110… Supported by CZI Science

Role of clonal inflammatory microglia in histiocytosis-associated neurodegeneration: Neuron cell.com/neuron/fulltex…

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins: Cell Stem Cell cell.com/cell-stem-cell…

It was fun to learn about blood vessel organoids together with Marina Nikolova and Treutlein lab! Thanks to Reiner Wimmer and PenningerLab for introducing us to this system! cell.com/cell/fulltext/…. Great support from editors and reviewers Cell!

Thrilled to share our review just published in Neuron! Big shoutout to Ava, Mengmeng , and our entire team! authors.elsevier.com/a/1k-uh3BtfHC%…

Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines: Cell Stem Cell cell.com/cell-stem-cell…

Congrats to the authors ⁦Yale University⁩ on this exciting and important work! #BrainTCellsRule || The subfornical organ is a nucleus for gut-derived T cells that regulate behaviour | Nature nature.com/articles/s4158…

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia | Acta Neuropathologica link.springer.com/article/10.100…

Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease: Immunity cell.com/immunity/fullt…

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy | Nature Neuroscience nature.com/articles/s4159…

Glymphatics and meningeal lymphatics unlock the brain-immune code: Immunity cell.com/cell-reports-s…

Our new study by Siling Du reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…

Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function: Immunity cell.com/immunity/fullt…

Using newly developed mouse models and a microglia replacement strategy, researchers in Science show that bone marrow transplantation could be used as an effective therapy for ALSP, a rare and fatal neurodegenerative disease. 📄: scim.ag/4kW4jsR #SciencePerspective:

Using newly developed mouse models and a microglia replacement strategy, researchers in Science show that bone marrow transplantation could be used as an effective therapy for ALSP, a rare and fatal neurodegenerative disease. 📄: scim.ag/4kW4jsR #SciencePerspective:

Nature research paper: Programmable protein ligation on cell surfaces go.nature.com/40HmcEs

Exciting finding led by Dr. Bruce Yankner: Endogenous lithium is essential for brain health and its deficiency contributes to the onset and progression of Alzheimer’s disease, by activating GSK3β—leading to impaired Aβ clearance and synapse loss 🔗 doi.org/10.1038/s41586…

Therapeutic genetic restoration through allogeneic brain microglia replacement | Nature nature.com/articles/s4158…