Interesting read! A few years ago we found “springs” to be common in our study of gene regulatory maintenance of cell identity in response to environmental perturbation. That’s exactly how we described it, too. See Fig. 1 of doi.org/10.1016/j.cels…

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Our new preprint is out!

“Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations”
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biorxiv.org/content/10.110…

The superteam of Indranil Singh and Dani Fernandez tackled a major unanswered question in HSC bio.
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Great opportunity!

Such a lively crowd and exciting discussions at Computational Health Center @[email protected] !

In two weeks we take synbio to the field: CRISPR diagnostics for crop pathogens!

Gates Foundation sponsoring Northwestern CSB Northwestern Maseno University, PHEL New Zealand and Pamoja CBO-Partners in Community Transformation to go to Kisumu, Kenya.

Follow #synbiofortheplanet to see our prep and time in the field!

(1/3) Excited to share our newest publication!! Fun collaboration with the Chen and Severinov labs to investigate how the fluoride riboswitch rearranges a pseudoknot to form a terminator. See movie generated by Elise White 🏳️‍🌈🏳️‍🌈 and Alan Chen (@TheRNAInstitute)

academic.oup.com/nar/article/do…

It was wonderful to present our latest work at the annual meeting of NSF-Simons Math-Bio institute at the Flatiron Institute in NYC! Also enjoyed meeting several other q-bio folks!

What are some options for cages for microscopes? OKOlab is one, anything else? There's always the machine shop if it comes to that. Any advice would be appreciated!

The Liao lab is looking for a postdoc/research scientist! Areas: Cytoskeleton, biophysics, or related. $$ with exciting projects, supportive environment. Boston beckon! Please, retweet! jobrxiv.org/job/northeaste…

New preprint alert! 🚨🚨

Droplet-based single-cell profiling of somatic epimutations enable high-res natural lineage tracing.

A super fun collaboration with Centre for Genomic Regulation (CRG), co-supervised with Lars Velten, and co-led by Michael Scherer and Indranil Singh!

biorxiv.org/content/10.110…

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in Science Magazine. Huge congratulations to co-first authors Umakant Sahu and Elodie Villa! science.org/doi/10.1126/sc…

This has been a long but exciting journey, but the findings are now published.

We have utilized Auxin-induced degron to rapidly deplete lamin proteins to see how they regulate the genome. The results were more interesting than we initially thought!

genomebiology.biomedcentral.com/articles/10.11…

Admission portals for Masters and PhD programs IIT Bombay are open. Prospective applicants pls consider applying to programs of Chemical Engineering IITB. I am excited to host first grad student(s) in my group . RTs highly appreciated.
portal.iitb.ac.in
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Announcing the inaugural Chicago Bioengineering Conference! We have a fantastic list of speakers, great venue in downtown Chicago, in the best Chicago weather Sept 30-Oct 1. In collaboration with
Chan Zuckerberg Biohub Network The University of Chicago Northwestern University of Illinois
czbiohub.org/events/chicago…

Our paper 'A mathematical model for the within-host (re)infection dynamics of SARS-CoV-2' is now online #MathematicalBiosciences ! 🦠💻📰🎉
Take a look here 👀
doi.org/10.1016/j.mbs.…

exciting opportunity!

We are delighted to announce that Dr. Ertugrul Ozbudak will join the Cell & Developmental Biology Department at Northwestern Feinberg School of Medicine!
feinberg.northwestern.edu/sites/cdb/facu…

Why are some non-antibiotic drugs toxic to bacteria 💊☠️🦠? Do they work like standard #antibiotics (ABX)? Our latest work by Mariana Noto published Science Magazine addresses this fundamental question (1/n)
science.org/doi/10.1126/sc…

ScRNAseq is a single-molecule, single-cell quantification of gene expression.... Editors/reviewers could consider to stop asking for qPCRs to 'validate' findings (especially if there is a robust number of counts per cell in the sc data)... qPCR is not smFISH

Thrilled to be spending a week as a Simons visitor at Living Machines-NCBS Simons Centre for the Study of Living Machines hosted by Shaon Chakrabarti and Archishman, and a day at IISc Bangalore with my friend & collaborator Mohit Kumar Jolly ! my student Madeline Melzer joins for 3 days as well