Protein codes promote selective subcellular compartmentalization | Science science.org/doi/10.1126/sc…

Autophagy ♻️ can't happen without PI3KC3-C1, a protein complex that initiates the cell’s cleanup by phosphorylating lipids 🧪 Congrats to the Michael Lazarou, Hummer Lab & Hurley Lab on their new publication!

A new study expands the “molecular grammar” of drivers of phase separation for the protein FUS nature.com/articles/s4158…

Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in Nature Methods! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N

Machine Learning Methods to Study Sequence–Ensemble–Function Relationships in Disordered Proteins 1/ This review explores how machine learning (ML) is revolutionizing the study of intrinsically disordered proteins (IDPs), which lack stable 3D structures and instead exist as

1/ In my final project as part of the Corry Lab, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations.. biorxiv.org/content/10.110…

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more: scim.ag/4iT8mpD

Now online! Cell membranes sustain phospholipid imbalance via cholesterol asymmetry dlvr.it/TJz9xs

Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ Jan Philipp Kreysing, Johannes Betz,Turoňová lab, Marina Lusic, Hummer lab, Beck Laboratory, Max Planck Institute of Biophysics 🔗 Preprint here: doi.org/10.1101/2025.0…

New preprint: TS2CG v2, building and simulating membranes with any shape and lateral organisation. We got Martini Globe, Martini Möbius strip and again mitochondrion. biorxiv.org/content/10.110… Siewert-Jan Marrink Source code: github.com/weria-pezeshki…

Nature research paper: Structural basis of lipid transfer by a bridge-like lipid-transfer protein go.nature.com/4itODM4

Subchromosomal mechanics of pericentric and centromeric chromatin along stretched mitotic chromosomes - surprise is little effect of CENP-N and -C degradation on CENP-A organization pubmed.ncbi.nlm.nih.gov/39937678/ From Ron Biggs and StraightLab #centromere #kinetochore #chromosome

A Perspective by Stephanie Wankowicz and James Fraser discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery nature.com/articles/s4158…

How cells wrap around coronavirus-like particles using extracellular filamentous protein structures, Sarthak Gupta et al Sarthak Gupta, Ali Patteson phd, Syracuse University Physics #SolidMechanics #Biophysics go.aps.org/3YlGUbG

TMEM170 family proteins are lipid scramblases that physically associate with bridge lipid transporters BLTP1/Csf1 biorxiv.org/content/10.110… #biorxiv_cellbio

How do powerful HIV antibodies bind both virus and membrane? Multi-scale simulations reveal the role of lipid interactions in neutralisation and what it means for vaccine design. elifesciences.org/articles/90139…

High-Speed Multiplexed DNA-PAINT Imaging of Nuclear Organization Using an Expanded Sequence Repertoire Abhinav Banerjee et al. doi.org/10.1101/2024.1…

Excited to share our #biorxiv preprint.

Helfrich Monte Carlo Flexible Fitting: physics-based, data-driven cell-scale simulations biorxiv.org/content/10.110… #biorxiv_biophys

Nice work from Chelsea Brown: she used integrative modelling to build and simulate a mitochondrial cristae (rdcu.be/eujAC).