mRNA localization and thylakoid protein biogenesis in the filamentous heterocyst-forming cyanobacterium Anabaena sp. PCC 7120 biorxiv.org/cgi/content/sh… #bioRxiv

Dual function of LapB (YciM) in regulating Escherichia coli lipopolysaccharide synthesis | PNAS pnas.org/doi/10.1073/pn… Glad to share our latest paper! We found LapB not only works as an adaptor protein to stimulate LpxC degradation by FtsH, but also regulates LpxC's activity

The 60-year evolution of lipid nanoparticles for nucleic acid delivery bit.ly/4ctrAyE This new Perspective article discusses advances in LNP research over the past 60 years and how this technology could overcome delivery challenges for gene therapy

Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency go.nature.com/3RYbPHK

Journal cover Nucleic Acids Res highlights our new method, RNAscape, for mapping base pairing and tertiary interactions in RNA structure: academic.oup.com/nar/article/52…. Same NAR issue features our new deep learning method to predict DNA shape: academic.oup.com/nar/article/52… USC Dornsife College of Letters, Arts & Sciences USC Research

Highly recommended! Forever young: what science can and can’t tell us about cheating ageing nature.com/articles/d4158…

Scientists should get paid for thinking time nature #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science

Our results finally explain the essential role of snR30 snoRNA! Check out the details in our preprint to find out more 👉👉👉 biorxiv.org/content/10.110… #ribosome #cryoEM #RNA

A new nanopore sequencing method can translocate long proteins, enabling detection of single amino acid substitutions and PTMs across protein strands up hundreds of amino acids. #NBThighlight go.nature.com/3MJK1UC

Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation go.nature.com/47EXbfq

Mammalian gene expression is controlled by an RNA switch system go.nature.com/3NMGcyO rdcu.be/dUSOe

We discovered 3 RNA families that form homo-oligomeric RNA-only complexes! Studying nature continues to expand my wildest imagination. Read about it: doi.org/10.1101/2024.1… Vivian Wu, Svetlana Shabalina, Hyunbin Lee, Grace Nye, Eugene Koonin, Alex Gao, Das Lab chiulab stanford

Research briefing of our circRNA paper Nature Biomedical Engineering is also online now: nature.com/articles/s4155…. Thank @MRC_LMB and The Leverhulme Trust for supporting the research.

Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage | Science science.org/doi/10.1126/sc…

I am more than happy to see this story to be out. We show another inhibition manner to Acetyl-CoA synthetase. Great thanks to mentor Gert and Joh. also great thanks to my best old friend Yifei as well as all contributed 🍀🍀🍀

New online! Structural insights into higher-order natural RNA-only multimers bit.ly/4m6opSt

Excited to share that my PhD thesis work is out in Science Magazine today. We demonstrate robust rearrangement of the human genome using bridge recombinases, performing programmable insertions, excisions, and inversions at megabase-scale.