Physicians can't take free pens.

This is pretty striking. Take one single cell experiment, split it into random 'batches', correct the batches, and look at change in nearest neighbor cell rank. Big changes (not good)!

Inspiring having Nancy Lee at Mass General Cancer Center Women in Cancer Grand Rounds‼️

Dr. Lee hit it out of the park (⚾️😊) with her talk on #precisiononcology for HPV+ HNSCC. Cool story & clinical concept to de-escalate #radiotherapy 💪🙏

➡️ascopubs.org/doi/abs/10.120…

#radbio #radonc

James Caudell Laila Gharzai MD LLM Interesting LRPFS still fit the bill, but I presume that's largely due to the early trials investigating C225+RT. Probably needs updating in due course with the newer studies.

Norm was my friend, and a great mentor, confidant and colleague. Both a medical oncologist and a radiation oncologist, he brought a wealth of knowledge and wit to everything he did.

Lots of activities in the space of liquid biopsy in viral-associated HNC #HNCS24

I see homologous dilemmas between HPV & EBV HNC
- Which assay
- How to risk stratify
- Individualising tx based on ctDNA (prob the most difficult question)

Nadeem Riaz Michael Mejia
C. Jillian Tsai, MD, PhD

Excellent editorial on academic predictive models and why they rarely translate

🔬 Exciting News! Our manuscript, 'scGPT: toward building a foundation model for single-cell multi-omics using generative AI' is now finally published in Nature Methods (@NatureMethods) 🎉 !!!

(Re-)Introducing scGPT: A transformative foundation model engineered for single-cell…

Thoughtful, well-informed counterpoint on the use of UMAP for visualising human genetic data, following the intense debate about the All Of Us paper this week.

Cephalopods are an incredible clade of animals and much of their biology is a mystery. I'm thrilled to share our new preprint, led by Gabrielle Coffing, describing an amazing discovery--ZZ/ZO karyotypes in cephs and the oldest sex chromsome found to date
biorxiv.org/content/10.110…

Thrilled to share our latest work out now in Science Magazine demonstrating a heterozygote advantage at HLA-II in protecting against lung cancer risk in smokers!

Check out Diego Chowell’s tweetorial below👇

Does the immune system protect against cancer?
Today our study on HLA immunogenetics and lung cancer risk has been published in Science Magazine led by Chirag Krishna Anniina Tervi Miriam Saffern Eric Wilson Hanna M Ollila Robert Samstein science.org/doi/10.1126/sc…

Does the immune system protect against cancer?
Today our study on HLA immunogenetics and lung cancer risk has been published in Science Magazine led by Chirag Krishna Anniina Tervi Miriam Saffern Eric Wilson Hanna M Ollila Diego Chowell science.org/doi/10.1126/sc…

Mutational signature analysis has become a key tool for interpreting somatic mutations. Our tool MuSiCal (Mutational Signature Calculator) by the amazing Hu Jin (Hu Jin) and Doga Gulhan (@dcgulhan) is out at Nat Genetics: nature.com/articles/s4158…. Three key ideas below.

#ICYMI : JNCI has launched an Early Career Investigator Research Section!

ECIs are important drivers of scientific discovery but may face hurdles when submitting manuscripts for publication in top-tier journals.

Find out how we're addressing this here: oxford.ly/47UV712

Prof Sir A Epstein was a true giant in my 'little' field of #NPC
Hard to fathom how this discovery made years ago had made such a diff to how we treat #NPC today
Despite the greatness, guess it always boils down to the experiences & silly things that stay with us (last para) 😅

We did 370 experiments to discover that protein language models primarily learn structure and won't scale for protein function prediction.

We need new pretraining tasks!

Work led by Francesca-Zhoufan Li with Ava Amini Yisong Yue Alex Lu

See Alex's thread + the paper for more!

1/ Not every #oncogene acts like an oncogene – context is key. Here, with the Varmus Lab Wang Congming Wang Congming_MeyerCancer, we demonstrate an ‘oncogene’ in the wrong cell type doesn’t act like an oncogene anymore. science.org/doi/epdf/10.11…

T cell lymphoma mutations power adoptive T cell therapies! Excited to see this published! A true collaboration with friend and colleague @koleroybal and our students @jay__daniels and #julie_garcia .
nature.com/articles/s4158…