PRESS RELEASE: Ranok will present a poster at the AACR Annual Meeting on Saturday 10 April 2021: “Chaperone-mediated protein degradation (CHAMP): A novel technology for tumor-targeted protein degradation” (Poster #971) #AACR21 ranoktherapeutics.com/newsdetail.htm…

This year, for the first time, the Marsilius Kolleg is awarding 8-12 one-year "Young Marsilius Fellowships for Interdisciplinary Research and Science Communication". The application deadline is 31 July 2021📝🗓 More information: marsilius-kolleg.uni-heidelberg.de/YoungMarsilius…

How Wnt production is regulated by the #Ubiquitin system: new study systematically identifies protein interaction partners of the Wnt cargo-receptor Evi/Wntless. Great work by Lucie Wolf journals.biologists.com/jcs/article/do… #Wnt #signaling J Cell Science

The PROTACtable genome go.nature.com/3wUIroz This article presents a systematic approach using a series of criteria based on public resources to support decision-making on whether a given target may be amenable to targeted protein degradation with a PROTAC

We have a postdoctoral position available to develop and apply single-cell perturbation approaches in tissues. Part of the ERC Synergy project with @wolfgangkhuber Jan Lohmann Oliver Stegle European Research Council (ERC) sciencedirect.com/science/articl… Apply here: nature.com/naturecareers/… Please RT

Postdoctoral position in molecular biology and #ubiquitin available in our lab in Heidelberg! The work will include teaming up with medicinal chemists and structural biologists to develop #PROTACs against CoV2 targets, exciting collab with Dikic lab jobrxiv.org/job/center-for…

Please RT: Want to use #proteomics to study protein degradation and #PROTACs with us? Postdoc position funded by PROXIDRUGS. Collaboration with Hummer Lab. jobrxiv.org/job/frankfurt-…

Tennisprofi Alexander Zverev gewinnt Olympia-Gold spiegel.de/sport/olympia/… via DER SPIEGEL

Have you heard the news? Ivan Đikić and Stefan Knapp just got honoured as #HighlyCitedResearchers! Huge congratulations to both our #PROXIDRUGS team members! Clarivate for Academia & Government #HighlyCited2021 @BMBF_Bund #zukunftscluster #Culsters4Future

Very happy to see our work on antibacterial gold NHC complexes published ! Many thanks to Brönstrup Lab and Peter G. Jones for the ongoing collaboration ! The article is available open access at: …mistry-europe.onlinelibrary.wiley.com/doi/epdf/10.10…

The well-known tumor-suppressor & oxygen-sensing molecule, VHL, is now shown to regulate the biological outcome of the TGFb pathway in cancer cells and during Drosophila wing development. From Zhou, Dabiri, Cheng Uni Heidelberg & colleagues bit.ly/3ItlFeD #CellSignaling

our new paper found the link between transforming growth factor beta (TGFß) and well-known tumor supporssor VHL! x.com/JCellBiol/stat…

Why do some people with #COVID19 get sicker than others? Although many factors govern how sick people become, a key driver of the severity appears to be genetic, which is common for other human viruses. Learn more in a new #SciencePerspective: fcld.ly/itsb6vn

The approach is easily scalable for the rapid growth of combinatorial libraries and potentially adaptable to any docking algorithm. #drugdiscovery nature.com/articles/s4158…

Richard Wombacher and colleagues (WombacherLab) report a new chemical inducer of proximity based on ABA receptor dimerization by the agrochemical manipropamid. Open access: nature.com/articles/s4158…

Check out our new manuscript where we describe efficient synthesis and in vitro enzymatic processic of UDP-GlcNAc-RNA! Now on Biorxiv! biorxiv.org/content/10.110…

Molecular Marvels: Small Molecules Paving the Way for Enhanced Gene Therapy mdpi.com/2616702 #mdpipharmaceuticals via MDPI

‘Obviously ChatGPT’ — how reviewers accused me of scientific fraud nature.com/articles/d4158… What do you support, a ChatGPT-, or non-ChatGPT- or ChatGPT-revised manuscript?

Thalidomide derivatives degrade BCL-2 by reprogramming the binding surface of CRBN: Cell Reports Physical Science cell.com/cell-reports-p…

Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing academic.oup.com/nar/article/do… I'm thrilled to announce that our paper "Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing" has been published in Nucleic Acids Research! 🎉