Super excited to share the news about our beloved Professor Marlene Belfort on being awarded the 2023 RNA Society Lifetime Achievement in Science Award! Cherry on top moment here on #InternationalWomensDay2023

A systematic search for RNA structural switches across the human transcriptome biorxiv.org/cgi/content/sh…

Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing nature.com/articles/s4192…

Secondary Structure Detection Through Direct Nanopore RNA Sequencing biorxiv.org/cgi/content/sh… #bioRxiv

How do LINE family retrotransposons jump around? Can we reprogram retrotransposons? What does this have to do with Rum and Raisin? Answers here and below!

Our genomes are littered with *junk* DNA known as LINE retrotransposons, which are powerful enzymes that can insert DNA into the genome. We are excited to report the structure of the LINE family member R2 and ways to engineer it for programmable gene insertion. Congratulations to

Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease dlvr.it/SmvbMy

Excited to share with everyone our study on precise targeted DNA insertions in plants! This technology and others will further enable precision breeding to develop sustainable agricultural products and climate resilient crops. Congrats to all co-authors and Caixia Gao !!🧬🌱🌾

It's been a week folks! The project that defined my PhD has been published today in nature: nature.com/articles/s4158…. Congrats to everyone involved in this work and a huge thank you to Hashim and Dan for their mentorship!! Also, my name is not a typo ! 1/2

🚨1st paper from my 1st PhD student Cleis 🥳 We discover that DNA loops are "geometric catalysts" for DNA integration and study how 1D/3D loop organisation affect integration site-selection in DNA and chromatin. #transposons #hiv #proudPI biorxiv.org/content/10.110…

Online Now: Mechanisms of insertions at a DNA double-strand break dlvr.it/Srfgq1

What will be the best modality for programmable RNA antibiotics? In our new work, we’ve compared half a dozen RNA, DNA and analogous molecules, looking at how good they are at suppressing an essential gene/mRNA in Salmonella. Encouraging results! biorxiv.org/content/10.110…

Pleased to share our new article "RNA folding studies inside peptide-rich droplets reveal roles of modified nucleosides at the origin of life" out at Science Advances. Collaboration with Keating lab. science.org/doi/full/10.11…

We did it! FDA IND clearance of NTLA-2001! I’m so proud of our team. Congrats to all! A big thank you to our clinical trial participants and sites, as well as our investigators who are contributing to the advancement of our therapies. The future looks bright! #OneIntellia

📰Hot off the press📰: Carolyn Kraus & ErikSontheimerLab News & Views Nature News & Views: Viruses use RNA decoys to thwart CRISPR defences nature.com/articles/d4158…

All-atom RNA structure determination from cryo-EM maps go.nature.com/3URIilo

#newscience alert in @naturecomms ! How can you make Nme2Cas9 editing Harder-Better-Faster-Stronger? Check it out! pubmed.ncbi.nlm.nih.gov/38368418/

Super excited to share our new preprint! We show: - circRNAs are super stable in the brain - that's why they accumulate with age in the brain - they can even be used as life experience markers! kudos to all the authors K. Kirio, Inés Lucía Patop et al. biorxiv.org/content/10.110…

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Our latest work is out in nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 nature.com/articles/s4158…