Mapping the energetic and allosteric landscapes of protein binding domains Step 0.1 in solving molecular biology Andre Faure @ajfaure.bsky.social Júlia Domingo Joern Schmiedel cristina hidalgo-carcedo Guillaume Diss nature.com/articles/s4158…

Join us & Genome Data Science lab! Fundamental question + systematic approaches + multiple down-the-line applications 🔥

Here it is: the allosteric map of a protein. Want to find all the sites to target in your favourite undruggable protein? Here's how you can do it. >22k biophysical measurements for one protein (KRAS) Congratulations to Chenchun Weng and Andre Faure @ajfaure.bsky.social biorxiv.org/content/10.110…

Excited to start recruiting postdocs + research assistants to my lab Wellcome Sanger Institute Massive mutagenesis to make biophysics + human genetics predictive? allostery, affinity, stability, splicing, receptors, TFs, cancer. pls RT tinyurl.com/bmb9vv5s tinyurl.com/49f3ubc3

Congratulations to our very own Ben Lehner for being elected a Fellow of the The Royal Society, the UK's prestigious national academy of sciences. Ben has been recognised for his outstanding contributions to science made over almost two decades at the CRG crg.eu/en/news/ben-le…

[2-1］Understanding how mutations combine to influence traits is a major challenge in genetics. In diploids, mutations of a gene can be on the same or different chromosomes. We lack direct comparisons of genetic interactions within & between alleles. nature.com/articles/s4146…

[2-2] Using thermodynamic models, we found that even simple systems show plastistic genetic interactions. For instance, a change in ligand concentration can switch dominance. #Genetics #biophysics with Ben Lehner nature.com/articles/s4146…

At Wellcome Sanger Institute we are recruiting 3 new faculty (at any level) in Generative Biology / AI/ML / Synthetic Genomics. Really well-funded positions with access to Sanger's unique capacity for large-scale data generation and long-term projects. pls RT! sanger.wd3.myworkdayjobs.com/en-US/Wellcome…

A chance to work with an amazing team of people on cool projects in an awesome city! Hurry up!

I was busy, and it was not a quick question

Very, very happy to finally share this: Energetic portrait of the amyloid beta nucleation transition state Anna Arutyunyan Mseu Andre Faure @ajfaure.bsky.social Benedetta Bolognesi Wellcome Sanger Institute Centre for Genomic Regulation (CRG) IBEC biorxiv.org/content/10.110…

Not to brag but im pretty sure i run faster than those Olympics guys when trying to finish experiments before the last bus #PhDlife #lablife #cellmates #cellmatescartoons

At ALLOX we now have 3 computational positions available! 📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t 📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke 📌Computational Chemist 👉 tinyurl.com/5n6vpem3 Apply or repost to help us spread the word 🙏

Thrilled to share new work led by Jie Yang in the lab published today in nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. Cambridge University CRUK Cambridge Centre rdcu.be/eci1U

New publication. We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With Benedetta Bolognesi Centre for Genomic Regulation (CRG) Wellcome Sanger Institute IBEC science.org/doi/10.1126/sc…

how mutations affect protein aggregation

One week left to apply for the postdoc position in my lab University of Oxford ! Join our exciting cancer immunology research at OxfordOncology, Oxford Cancer & Centre for Immuno-Oncology. Deadline: 11 August 2025 (noon).

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by Xianghua (Cici) Li Are Transcription Factors really 'undruggable'? biorxiv.org/content/10.110…

🚀 We’re hiring a PhD! Fully funded studentship available at King’s College London: 🔗 findaphd.com/phds/project/m… Deadline of Application: 7 Nov 2025 Open to UK home-fee students. Please help spread the word! 🙏 #PhD #Genetics #FunctionalGenomics #Allostery #TFMAPS