The guide RNA sequence dictates the slicing kinetics and conformational dynamics of the Argonaute silencing complex biorxiv.org/cgi/content/sh… #bioRxiv

Check out our new preprint, part 1: Control of poly(A)-tail length and translation in vertebrate oocytes and early embryos biorxiv.org/content/10.110…

Check out our new open access paper on regulation of poly(A)-tail length and translation during oocyte maturation and early embryogenesis. Great collaboration with Jimmy Ly from the Iain Cheeseman lab. authors.elsevier.com/sd/article/S15…

New preprint now live! We find that translation start site selection is dramatically rewired during mitosis through an elegant mechanism involving the nuclear release of eIF1. Want a play-by-play of major findings? - check out last week's teaser posts. biorxiv.org/content/10.110…

A new reagent for in vivo structure probing of RNA G and U residues that improves RNA structure prediction alone and combined with DMS dlvr.it/T65dBD

In the latest issue! The purpose and ubiquity of turnover dlvr.it/T7TP4m

Glad to finally share our paper in its published form, in which we deciphered the RNA sequence determinants and conformational requisites of AGO2, the cellular machinery for RNAi: cell.com/molecular-cell…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.