This first-in-class CCNE1 degrader from Monte Rosa is really impressive. It's a molecular glue that finds a shallow pocket on CCNE1 and displays cooperative binding to CRBN, w/ EC50 of 3 nM for the ternary complex. Highly specific CCNE1 degradation. ir.monterosatx.com/static-files/d…

Fascinating work showing that the covalent addition of a nuclear importing compound, JQ1, to therapeutic oligonucleotides enhances their activities by enhancing nuclear penetration.

I've really enjoyed working with Will the past few years and would highly recommend his lab to anyone interested in chem bio/cancer bio

tfw you put out a postdoc ad

The first time I saw "metformin effect" on a PET/CT for one of my patients, I was bowled over; it is not subtle. Now some quantification of how metformin causes the gut to excrete glucose, maybe a hint at its mechanism of action. ***How does a molecule like that achieve this!?

Gillmore and colleagues report 24-month results from a phase 1 study of nexiguran ziclumeran, a CRISPR gene-editing approach to treating hereditary transthyretin amyloidosis with polyneuropathy. Full study results: nej.md/46Qhur7 #Neurology #Genetics

Algorithmic inference from large scale functional genomic screens may now generate actionable insights into tumors too rare to profile directly. Excellent work from Ananthan Sadagopan and Srinivas Viswanathan