The anti-MUC1 antibody we sequenced by mass spec is now available on Addgene: addgene.org/browse/article… biorxiv.org/content/10.110…

And it's out! Check out our paper in nature on the human coronavirus HKU1 spike binding to a sialoglycan receptor, leading to spike opening via large conformational changes. Massive thanks to Daniel Hurdiss, Raoul J de Groot🥒&🌶 and all co-authors! nature.com/articles/s4158… #cryoEM

Interested in the fascinating field of microproteins? Join my group in a collaboration with @s_heesch at the PMC. PostDocs apply below: werkenbijprinsesmaximacentrum.nl/en/vacancy/pos… @hecklab PrinsesMáximaCentrum

Interested in site specific ABPP - Check out our preprint on BioRxiv by Wouter van Bergen!! biorxiv.org/content/10.110…

Excited to share our new antibody sequencing tools for proteomics data in Stitch. We implemented a mass-based alignment algorithm to improve sequence assembly. Check it out! github.com/snijderlab/sti… github.com/snijderlab/ali… biorxiv.org/content/10.110…

Congratulations Dr. Peng! weiwei defended her PhD thesis yesterday. Very proud of you!

A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen Joost Snijder weiwei Faculty of Science, Utrecht University bit.ly/3vb8U6F

Ever used a FLAG-tag and wondered how it is recognized by anti-FLAG M2? Check out our preprint where we determined a 💎crystal💎 structure of the complex: biorxiv.org/content/10.110… (FLAG peptide in pink in the video below) #structuralbiology #crystallography

Check out this paper recently published in LSA: Reverse engineering the anti-MUC1 antibody 139H2 by mass spectrometry-based de novo sequencing Joost Snijder weiwei Faculty of Science, Utrecht University hubs.la/Q02qdvJp0

Our paper Matti Pronker Wouter on the structure of anti-FLAG-M2 in complex with the FLAG-peptide (DYKDDDDK) is now peer reviewed Journal of Molecular Biology 🎉 sciencedirect.com/science/articl…

Join us in Berlin as a #postdoc or staff scientist! We have several great openings - both academic and joint with industry. We need: protein #massspec or #biochemistry expertise. We offer: cutting-edge infrastructure and an awesome team. DM for more info #TeamMassSpec #hiring

🔓 #OpenAccess + ACS Publications Editors' Choice + Most Read in the past 30 days: "Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme" pubs.acs.org/doi/full/10.10…

Awesome work by Dawid Zyla Erica OllmannSaphire, out today Science Magazine. Happy we weiwei could make a small contribution, check out the paper: science.org/doi/10.1126/sc…

I am excited to share our study in Science Magazine on #measles fusion glycoprotein in complex with the first neutralizing antibody described for this virus! doi.org/10.1126/scienc… /1

Vandaag stuk in Trouw over ontdekking antistof tegen de mazelen van Dawid Zyla en Erica OllmannSaphire. trouw.nl/ts-b09acf84/

So happy and proud that it’s finally out! My first PhD project😂😂😂

We built a rust library (rustyms) and the Annotator GUI to analyze any complex bottom-up or top-down peptidoform with any fragmentation, based on ProForma 2.0. Get it on github and read more in the preprint: biorxiv.org/content/10.110… github.com/snijderlab/rus… github.com/snijderlab/ann…

Presenting my antibody work at UT Austin core showcase for biological mass facility!

Welcome to my poster (033) at #ASMS2025 today!

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postF specific binding and antigenic site I. Now published in ACS Publications Infectious Diseases pubs.acs.org/doi/10.1021/ac… weiwei Xander de Haan Marta Siborova