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Great effort by Berta Marcó de la Cruz Göteborgs universitet / University of Gothenburg Sahlgrenska Academy and Joacquín Campos Uni Heidelberg, in a fantastic collaboration with the lab of Claudio Acuna! doi.org/10.1038/s41593…

Glad to be part of this feature on time-resolved cryo-EM by Ewen Callaway thanks to work done in the lab by @alejandraaaaa_r and Calli Bonin Johns Hopkins University Johns Hopkins Medicine. Greatly captures the promises and challenges with this burgeoning field.

Happy to share our community article from the last #neurophotonics meeting published in SPIE, along with my cover image! Endogenous AMPAR visualized with the AP-GluA2 KI toolkit and lattice light sheet #microscopy Interdisciplinary Institute for Neuroscience 🧠 BIC doi.org/10.1117/1.NPh.…

Years after the idea and preliminary experiments, Claire Coupland's amazing structure of the endogenous vacuolar- or vesicular-ATPase in its native vesicle is now in bioRxiv "High resolution cryo-EM of V-ATPase in native synaptic vesicles" biorxiv.org/content/10.110…

Happy to share our new paper on the structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Collaboration between V. Chubanov, A. Sobolevsky Alexander Sobolevsky and M. Kurnikova Maria Kurnikova labs. Kirill Nadezhdin Arthur Neuberger cell.com/cell-reports/f…

Cal-ID, a calcium-dependent protein proximity labeling tool, is finally published Nature Chemical Biology! We (Nicholas Ingolia) present a simple, scalable, in vivo compatible, and versatile platform that connects calcium signals to biochemical labeling of proteins. rdcu.be/dFDrb

I am excited to introduce the OneNeuro Initiative at Johns Hopkins University @OneNeuro, which is uniting, expanding, and reimagining neuroscience research and education at the University.

Happy to share structural mechanism of kainate receptor activation. Channel opening involves kinking of all four pore-forming M3 helices! Shanti Pal Gangwar Maria Karela Kirill Nadezhdin Laura Yen Maria Kurnikova disq.us/t/4oqzkgx

This project wouldn't have been possible without the support of my excellent mentors Rick Huganir and Ed Twomey as well as our fantastic collaborators Dr. Vasanthi Jayaraman Cuauhtemoc Ulises @alejandraaaaa_r and Albert Lau. A great collaboration! More yet to come!

Using #cryoEM, scientists Ed Twomey, Rick Huganir and colleagues have determined how a widely-used #epilepsy drug works. The findings could eventually help with designing new drugs that target #brain cells’ AMPA receptors. bit.ly/3VkKEIc

Using #cryoEM, scientists Ed Twomey, Rick Huganir and colleagues have determined how a widely-used #epilepsy drug works. The findings could eventually help with designing new drugs that target #brain cells’ AMPA receptors. oneneurojhu.org/2024/06/10/sup…

Huge step forward!!! "Molecular mechanism of ligand gating and opening of NMDA receptor" from Furukawa Lab CSHL and team out in nature This not only uncovers the NMDAR activation mechanism, but also the dual agonist requirement. nature.com/articles/s4158… #cryoEM

UPDATED: We have identified 492 funding opportunities for early-career researchers/faculty. Download for free the database here: research.jhu.edu/rdt/funding-op… For each entry, we provide description, deadline, $ amount, eligibility, link to funder.

Patent examiners see the latest inventions before the public, and we’re hiring in many science and engineering fields. You can also work from your location of choice in the U.S. and Puerto Rico. Join us at the forefront of innovation and apply now: bit.ly/patent-25.

A postdoctoral fellow position in the Huganir lab is open immediately to study the dynamic synaptic proteome using proximity labeling techniques in vivo during synaptic plasticity and learning and memory in health and disease. If interested, please send a CV to [email protected].

Can confirm - this is a great lab to work in. Check it out!

Now on bioRxiv - Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs 🧠🔥❄️🔬 In this preprint, we reveal how glutamate gating of iGluRs is unique from PAM-activated states (!!!), and how temperature effects glutamate gating. biorxiv.org/content/10.110…

Awesome work Anish Kumar Mondal Ed Twomey and Dr. Vasanthi Jayaraman !

Awesome lineup of scientists for our annual postdoc Rising Stars Symposium 🙌 Keynote Elizabeth Villa!

I could not be more excited for this! Thank you University of Utah Health and U of Utah Department of Neurobiology for the invitation. This is going to be a great symposium!