beautiful work! have been waiting for this for a while! congrats Josh Tycko

amazing work! congrats Mo!

Bravo Adam Broerman! Really beautiful old-school design paper! this could open up new avenues for biosensor designs.

Finally out in Science Magazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific

Excited to finally share Perceptein, a PERCEPtron made of proTEINs: science.org/doi/10.1126/sc…

Congrats on this beautiful paper! Sudarshan Pinglay

Congrats @JONA. such beautiful paper

Beautiful work! congrats Yodai Takei !

Congrats Jingchuan Luo. Really novel way to study localized translation.

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published nature! Links to paper and tutorial below.

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.110…

pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.110…, we developed computational methods to rationally design pH-sensitive binders. 🧵

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”. This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6) doi.org/10.1101/2025.1…

Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & Green Ahn Institute for Protein Design on the work! Preprint: biorxiv.org/content/10.110…

The Wilkinson Lab is open for science! Memorial Sloan Kettering Cancer Center 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

absolutely excited to see Chengxiang Qiu starting his own lab at Dartmouth! Great adventure awaits!