I’m excited to share a new manuscript from my PhD! doi.org/10.1101/2024.0… We performed a genome-wide optical pooled screen (OPS) and identified hundreds of novel Ebola virus regulators.

🧵1/5 I'm so proud to share these incredible findings from our collaborative work with Amara Ali & Juan Reguera lab about Alphaviruses, particularly the chikungunya virus!! Highlights in the 🧵👇 nature.com/articles/s4146…

Congratulations to Zhijian “James” Chen, 2024 #LaskerAward winner! – “for the discovery of the cGAS enzyme that senses foreign and self DNA, solving the mystery of how DNA stimulates immune and inflammatory responses.” laskerfoundation.org/winners/cgas-e… #Lasker2024 #LaskerLaureate

big day for cGAS girlies

I have a new preprint! Uncovering hundreds of exogenous and endogenous RNA viral RdRp sequences amongst uncharacterised sequences in public protein databases biorxiv.org/content/10.110… 🧵1/6

Extremely excited to share this new paper from my graduate work in the Overbaugh lab! nature.com/articles/s4156… Nature Microbiology @FredHutch Seattle MCB Program

De novo creation of an innate immune LPS receptor. Anh Cao identified the principles of LPS detection by caspase-11, revealing the CARD as a bipartite lipid binding module. This knowledge allowed us to convert an ancient CARD-like protein into a functional LPS receptor.

We're happy to present our latest preprint, where we used cryoET to study tick-borne flavivirus replication in human cells and mouse brains! #cryoEM #virology biorxiv.org/content/10.110…

Our study at The Lancet Infectious Diseases demonstrated that 2023-24 Oropouche virus reassortant have increased virulence, fitness, and the ability to evade previous immunity generated by the previous Oropouche virus infection! 🦟🦠🇧🇷 Available: thelancet.com/journals/lanin…

The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level? Our latest work Andrea Pauli Cell Press reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8) cell.com/cell/fulltext/…

Excited to announce the first paper from our lab identifying a family of anti-inflammatory compounds from vaginal lactobacilli #microbiome #WomensHealth authors.elsevier.com/a/1jy2C6t8JEqo… (1/8)

What can cloud computing bring to the discovery of novel EVEs in vertebrate genomes? Rather a lot, really happy to share this work with José Gabriel Niño Barreat: rdcu.be/dXF4A

At the end of 2018 I was lucky to receive a CZI Science Ben Barres award. This preprint is the culmination of that funding, which allowed us to try "out of the box" ideas to study neurodegeneration. Fearlessly led by amazing student Mitali Tyagi! 🧵 /1 biorxiv.org/content/10.110…

New version of this paper just hit bioRxiv! Maureen Laroche 🇲🇶 and student as new co-authors, and their very interesting new data on vertebrate DNA detection in wild-caught male mosquitoes! Perhaps this is not just a crazy lab phenomenon after all! biorxiv.org/content/10.110…

Breakthrough vaccines against herpesviruses linked to cancer, MS, and dementia are within reach! I’m proud to share our latest work stabilizing the gB fusion protein 🦠 🔗 biorxiv.org/content/10.110… Please retweet! #herpesvirus #EBV #HSV #CMV #proteindesign #virology #immunology

Two new #cryoEM structures of #antibodies against H3N2 #influenza viruses from our collaboration with Schmidt Lab at Harvard Medical School ! biorxiv.org/content/10.110…

BREAKING: Rare imported case of #Lassa fever diagnosed in Iowa; person died from the infection, state health authorities reported Monday. statnews.com/2024/10/28/las…

🚨🚨 Our latest paper shows that IFITM3 deficiency lowers the minimum virus dose threshold for influenza and also enhances adaptation of the virus to a new species.🦠🫁 Major implications for preventing new pandemics. 😷 First author Parker J. Denz 👨‍🔬nature.com/articles/s4146…

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Are women not doing science in Europe or something?