How much do beta blockers help after a heart attack — even when the heart’s pumping well? We revisit the origins of beta blockers in post-MI care, examine how evidence evolved, and explore the REDUCE-AMI trial, which questions whether beta blockers are still needed for all. 🎧

Incidence of potentially disruptive medical and social events in older adults with and without dementia - Hunt - 2022 - Journal of the American Geriatrics Society - Wiley Online Library agsjournals.onlinelibrary.wiley.com/doi/epdf/10.11…

Most viewed this week from JAMA Neurology: APOE epsilon ε4 is a significant risk factor for intracranial hemorrhage in patients with atrial fibrillation on apixaban. ja.ma/3TJHNb8

Frailty poses a major public health challenge, yet it is a poorly understood condition globally. To address knowledge gaps and inform and develop effective public policy to prevent frailty, The Lancet announces a new Commission. Find out more ⬇️ hubs.li/Q03v0bwP0

APOE ε4 and Risk of Intracranial Hemorrhage in Patients With Atrial Fibrillation Taking Apixaban | Anticoagulation | JAMA Neurology | JAMA Network jamanetwork.com/journals/jaman…

Emergency Department Visits for Medication-Related Events With vs Without Pharmacist Intervention: The URGEIM Randomized Clinical Trial | Clinical Pharmacy and Pharmacology | JAMA Internal Medicine | JAMA Network jamanetwork.com/journals/jamai…

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emjreviews.com/neurology/news…

Our featured article for August is this Review, in which Raquel Taddei and Karen Duff consider the importance and mechanisms of synapse resilience and vulnerability in dementia. You can read it in full for free here: rdcu.be/eurPp Duff Lab

Osteoporosis is a common condition among older adults that leads to increased susceptibility to fracture. Learn more about the epidemiology, diagnosis, and treatment of osteoporosis in this review. ja.ma/44vb66r

Aspirin is one the most commonly used drugs worldwide. This practice article discusses prescribing considerations for aspirin bmj.com/content/390/bm…

Places claiming to be centenarian hotspots may just have bad data economist.com/graphic-detail…

Do you know how to pick the right pill for agitation in Alzheimer’s? There is new real world evidence now available from the journal Neurology by Julie Zissimopoulos and colleagues. Agitation in Alzheimer’s disease can be heartbreaking and dangerous. The FDA approved

Education and Accelerated Tau Accumulation in Alzheimer Disease jamanetwork.com/journals/jaman…

Inflammation in Neuropsychiatric Disorders jamanetwork.com/journals/jamap…

Denosumab and Fracture Prevention in Primary Care Practice | Trauma and Injury | JAMA Internal Medicine | JAMA Network jamanetwork.com/journals/jamai…

Clinical Management of Cerebral Amyloid Angiopathy mdpi.com/2077-0383/14/1…

Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt–Jakob disease: evaluation of a first-in-human treatment programme - The Lancet Neurology thelancet.com/journals/laneu…

Spoiler alert: Behavioral therapy matches drugs for urinary symptoms in Parkinson’s as shown by a newly published randomized study by Vaughan and colleagues in JAMA Neurology. Overactive bladder symptoms in Parkinson’s are under-appreciated and have a huge impact on quality of

Identifying common disease trajectories of Alzheimer’s disease with electronic health records - eBioMedicine thelancet.com/journals/ebiom…